The role of immune cells in immune tolerance mechanisms towards chronic hepatitis B
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摘要: 机体对乙型肝炎病毒(HBV)的免疫耐受是HBV感染慢性化的主要机制。急性、自限性HBV感染过程中存在强烈的、多特异性的细胞免疫应答。而在慢性感染者这种反应明显减弱,存在免疫耐受。本文旨在阐述免疫细胞在HBV免疫耐受机制中可能发挥的作用。Abstract: Immune tolerance to hepatitis B virus (HBV) is the major chronicity mechanism of HBV infection.Cell-mediated immune responses to HBV antigens are vigorous and multispecific in acute, self-limited infections, whereas in chronic infection the response was significantly attenuated with immune tolerance.In this article, the role of immune cells in the mechanisms of immune tolerance was reviewed.
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Key words:
- hepatitis B virus /
- immune tolerance /
- dendritic cells /
- T-lymphocytes /
- helper-inducer /
- T-lymphocytes
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