抑癌基因APC、RASSF1A、WIF-1启动子区域甲基化与消化系肿瘤

张慧景; 李胜棉

抑癌基因APC、RASSF1A、WIF-1启动子区域甲基化与消化系肿瘤

河北医科大学第四医院消化内科

基金项目:

河北省科技计划项目(09276101D-9)；

详细信息

中图分类号: R735
计量
- 文章访问数: 4632
- HTML全文浏览量: 15
- PDF下载量: 919
- 被引次数: 0
出版历程
- 出版日期: 2011-04-20

Promoter methylation in APC, RASSF1A, WIF-1 gene in digestive system tumors

Research funding:

摘要

摘要: 消化系统肿瘤是常见的人类恶性肿瘤,目前研究认为抑癌基因启动子区域的异常甲基化与肿瘤的形成有关。在此综述APC、RASSF1A、WIF-13种抑癌基因启动子区域的异常甲基化与消化系统肿瘤的关系。
- 消化系统肿瘤 /
- 基因,肿瘤抑制 /
- 原癌基因 /
- DNA甲基化 /
- 启动区(遗传学) /
- 基因,APC /
- 基因,Ras
Abstract: The digestive system tumor is very common amongst human malignant tumors.The recent research indicate that the aberrant promoter methylation plays an important role in the progression of tumor.This review summarizes the role of three suppressor genes APC, RASSF1A and WIF-1 and methylation in the carcinogenesis of digestive system.
- digestive system neoplasms /
- genes /
- tumor suppressor /
- proto-oncogenes /
- DNA methylation /
- promoter regions (genetics) /
- genes

HTML全文

参考文献(34)

[1]Herman JG, merlo A, Mao Li, et al.Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNAmethylation in all common human cancer[J].Cancer Res, 1995, 55 (20) :4525-4530.

[2]Rein T, Depamphillis ML, Zorbas H, et al.Identifying5-methylcytosine and related modification in DNA genes[J].Nucleic Acids Res, 1995, 55 (20) :4525-4530.

[3]Kamiyama H, Noda H, Takata O, et al.Promoter hypermethylation of tumor-related genes in peritoneal lavage and theprognosis of patients with colorectal cancer[J].J Surg Oncol, 2009, 100 (1) :69-74.

[4]Powell SM, Zilz N, Bryan TM, et al.APC gene mutation occurearly during colorectal tumorigenesis[J].Nature, 1992, 359 (6392) :235-237.

[5]Homma MK, Li D, Krebs EG, et al.Association and regulationof casein kinase 2 activity by adenomatous polyposis coliprotein[J].Proc Natl Acad Sci U S A, 2002, 99 (9) :5959-5964.

[6]Yutaka S, Chi WW, Yutaka K, et al.Epigenetic-Genetic Interactionsin the APC/WNT, RAS/RAF, and P53 Pathways in ColorectalCarcinoma[J].Clin Cancer Res 2008, 14 (9) :2560-2569.

[7]Kumar K, Brin H, Giardiello F, et al.Distinct BRAF (V600E) and KRAS mutations in high microsatellite instability sporadiccolorectal cancer in African Americans[J].Clin Cancer Res, 2009, 15 (4) :1155-1161.

[8]Tang M, Torres-Lanzas J, Lopez-Rios F, et al.Wnt signalingpromoter hypermethylation distinguishes lung primaryadenocarcinomas from colorectal metastasis to the lung[J].Int J Cancer, 2006, 119 (11) :2603-2606.

[9]吴龙, 钱叶本, 朱立新, 等.肝细胞癌中SFRP1和APC基因启动子甲基化与其mRNA的表达[J].中国普通外科杂志, 2008, 17 (1) :29-33.

[10]Kiran M, Chawla YK, Kaur J, et al.Methylation profiling oftumor suppressor genes and oncogenes in hepatitis virus-related hepatocellular carcinoma in northern India[J].CancerGenet Cytogenet, 2009, 195 (2) :112-119.

[11]Lee HC, Kim M, Wands JR, et al.Wnt/Frizzled signaling inhepatocellular carcinoma[J].Front Biosci, 2006, 11:1901-1915.

[12]Colnot S, Decaens T, Niwa Kawakita M, et al.Liver-targetedDisruption of Apc in Mice Activates Beta-catenin Signalingand Leads to Hepatocellular Carcinomas[J].Proc Natl AcadSci U S A, 2004, 101 (49) :17216-17221.

[13]Ksiaa F, Ziadi S, Amara K, et al.Biological significance of promoterhypermethylation of tumor related genes in patients with gastriccarcinoma[J].Clin Chim Acta, 2009, 404 (2) :128-133.

[14]Lee SH, Kang HJ, Shin DH, et al.Expression of beta-cateninand its mechanism of delocalization in intestinal-typeearly gastric cancer based on mucin expression[J].HistolHistopathol, 2009, 24 (7) :831-838.

[15]Esteller M, Sparks A, Toyota M, et al.Analysis of adenom-atous polyposis coli promoter hypermethylation in humancancer[J].Cancer Res, 2000, 60 (16) :4366-4371.

[16]Clement G, Braunschweig R, Pasquier N, et al.Methy-lation of APC, TIMP3, and TERT:a new predictive marker todistinguish Barrett's oesophagus patients at risk for malignanttransformation[J].J Pathol, 2006, 208 (1) :100-107.

[17]Brock MV, Gou M, Akiyama Y, et al.Prognostic importance ofpromoter hypermethylation of multiple genes in esophagealadenocarcinoma[J].Clin Cancer Res, 2003, 9 (8) :2912-2919.

[18]丁振, 钱叶本, 熊奇如, 等.肝细胞癌中WIF-1基因启动子甲基化状态及mRNA表达的研究[J].肝胆外科杂志, 2008, 16 (4) :304-307.

[19]张影, 张福奎, 王宝恩.经典Wnt信号通路与肝脏病的研究进展[J].世界华人消化杂志, 2008, 16 (9) :975-981.

[20]程勤, 金洁, 于彬, 等.肝癌细胞中WIF-1的甲基化状态分析[J].复旦学报, 2007, 34 (6) :843-847.

[21]郭艳丽, 郭炜, 靳国梁, 等.贲门腺癌WIF-1基因启动子区甲基化状态的检测及临床意义[J].第三军医大学学报, 2009, 32 (21) :2094-2097.

[22]Taniguchi H, Yamamoto H, Hirata T, et al.Freque-nt epigeneticinactivation of Wnt inhibitory factor-1 in human gastrointestinalcancers[J].Oncogene, 2005, 11 (53) :7946-7952.

[23]Lee BB, Lee EJ, Jung EH, et al.Aberrant methylation ofAPC, MGMT, RASSF2A, and Wif-1 genes in plasma as abiomarker for early detection of colorectal cancer[J].ClinCancer Res, 2009, 15 (19) :6185-6191.

[24]Taniguchi H, Yamaoto H, Hirata T, et al.Frequent epigeneticinactivation of Wnt inhibitory factor-1 in human gastrointestinalcancers[J].Oncogene, 2005, 11 (53) :7946-7952.

[25]Hu L, Chen G, Yu HP, et al.Clinicopathological significanceof RASSF1A reduced expression and hypermethylation inhepatocellular carcinoma[J].Hepatol Int, 2010, 4 (1) :423-432.

[26]周晓俊, 薛万江, 秦磊, 等.原发性肝癌中RASSF1A基因表达失活及其临床意义[J].江苏医药, 2007, 33 (1) :24-27.

[27]Chan KC, Lai PB, Mok TS, et al.Quantitative analysis ofcirculating methylated DNA as a biom arker for hepatocellularcarcinoma[J].Clin Chem, 2008, 54 (9) :1528-1536.

[28]刘培, 姜相君, 葛银林, 等.RASSF1A基因启动子区甲基化在胃癌组织中的检测[J].世界华人消化杂志, 2009, 17 (30) :3144-3147.

[29]蒋鹏程, 马圭, 孟鑫, 等.RASSF1A在胃癌中的甲基化检测及表达[J].现代肿瘤医学, 2009, 17 (6) :1115-1118.

[30]Tamotsu K, Francesco T, Sai Y, et al.Promoter Hype-rmethylation of RASSF1A in Esophageal Squamous CellCarcinoma[J].Clin Cancer Res, 2003, 9 (4) :1441-1445.

[31]Gonzalo V, Lozano JJ, Balaguer F, et al.Aberrant genepromoter methylation associated with sporadic multiplecolorectal cancer[J].PLoS One, 2010, 5 (1) :e8777.

[32]Sakamoto LHT, DE Camargo B, Cajaiba M, et al.MT1Ghypermethylation:a potential prognostic marker forhepatoblastoma[J].Pediatr Res, 2010, 67 (4) :387-393.

[33]Jin Z, Mori Y, Hamilton JP, et al.Hypermethylation of thesomatostatin promoter is a common, early event in humanesophageal carcinogenesis[J].Cancer, 2008, 112:43-49.

[34]董科, 李波, 覃扬, 等.5-氮杂胞苷抑制肝癌细胞恶性表型和逆转甲基化状态的作用及机制[J].世界华人消化杂志, 2008, 16 (17) :1842-1848.

施引文献

资源附件(0)

访问统计