PDF下载 ( 3039 KB)
Three dimensional conformation radiotherapy for 35 cases of unresectable massive primary liver cancer
-
摘要: 目的观察三维适形照射对不能手术的原发性大肝癌治疗效果。方法收集1997年10月至2008年6月不能手术的原发性大肝癌35例。肿瘤直径8～12 cm。根据Child-Pugh肝功能分级,A级26例,B级9例。采用三维适形放疗,每次照射剂量4～5 Gy,每周3次,总剂量50～55 Gy。结果放疗后2～3个月CT复查,CR 17.1%,PR 65.7%,NC 11.4%。1、2、3年生存率分别为71.4%、42.9%、20.0%,30例复查AFP,21例明显下降,其中8例恢复至正常水平。结论三维适形放疗对原发性肝癌有肯定的治疗效果,特别是对不能手术的大肝癌是一种有效的局部治疗手段。Abstract: Objective To evaluate the effect of three dimensional conformation radiotherapy (3-DCRT) for unresectable primary massive liver cancer.Methods From October 1997 to June 2008 35 unresectable massive primary liver cancer patients were analyzed, the tumor size were 8-12cm, including Child-Pugh Grade A and B respectively.The patients received 3-DCRT with total dose of 50-55 Gy, at 4-5 Gy/f, 3f/w.Results The CR was 17.1%, PR was 65.7%, and NC was 11.4% which were detected with CT images in 2-3 month after radiotherapy.1, 2 and 3 year survival rates were 71.4 %, 42.9% and 20%, respectively.AFP value in 30 cases was followed up.It was decreased significantly in 21 cases and 8 cases among them showed normal value of AFP.Conclusion 3-DCRT is effective in the treatment of liver cancer;especially for unresectable massive primary liver cancer, it is an effective local treatment method.
-
Key words:
- liver neoplasms /
- radiotherapy
-
[1]Avila MA, Berasainc C, Sangro B, et al.New therapies forhepatocellular carcinoma[J].Oncogene, 2006, 25 (27) :3866-3884. [2]王阁.原发性肝癌复发治疗中放射治疗的进步与展望[J].中华肝脏病杂志, 2007, 15 (8) :613-614. [3]徐从高, 张茂宏, 杨兴季, 等.癌—肿瘤学原理和实践[M].济南:山东科学技术出版社, 2001:1124. [4]Park W, Lim DH, Paik SW, et al.Local radiotherapy forpatients with unresectable hepatocellular carcinoma[J].Int JRadiation Oncology Biol Phys, 2005, 61 (4) :1143-1150. [5]Kim DY, Park W, Lim DH, et al.Three-dimensonal conformalradiotherapy for portal vein thrombosis of hepatocellularcancinoma[J].Caner, 2005, 103 (11) :2419-2426. [6]罗政, 饶建, 殷蔚伯.放疗在原发性肝癌治疗中的地位和现状[J].中华放射肿瘤学杂志, 2006, 15 (4) :345-346. [7]Liu MT, Li SH, Chu TC, et al, Three-dimensonal conformalradiation therapy for unresectable hepatocellularcancinoma patients who had failed with or were unsutedfor transcatheter arterial chemoemboliztion[J].Jpn J Cncol, 2004, 34 (9) :532-539. [8]周陈华, 陈华津, 王晓军, 等.中晚期肝癌三维适形放疗的临床观察[J].中华放射肿瘤学杂志, 2005, 14 (2) :129. [9]梁世雄, 蒋国梁, 朱小东, 等.原发性肝癌大分割三维适形放疗的预后因素分析[J].中华肿瘤杂志, 2005, 27 (10) :613-615. [10]王春刚, 肖作平, 居小萍, 等.大分割三维适形放射治疗不能手术原发性肝癌[J].中国癌症杂志, 2006, 16 (6) :481-483. [11]邹瑜斌, 杨云利, 梁世雄, 等.复发性肝癌大分割适形放疗的疗效及预后分析[J].肿瘤, 2009, 29 (10) :980-983. -
本文二维码
计量
- 文章访问数: 2778
- HTML全文浏览量: 11
- PDF下载量: 678
- 被引次数: 0
下载:
