肝细胞癌患者血清胸腺素β4水平

邢晶; 韩涛; 朱争艳; 刘莹; 刘华; 郭震; 马晓燕; 裴彦祯

肝细胞癌患者血清胸腺素β4水平

1. 天津医科大学三中心临床学院
2. 天津市第三中心医院
3. 天津市人工细胞重点实验室

基金项目:

国家重点基础研究发展规划基金资助项目(973计划)(2007CB512801)；国家“十一五”科技重大专项(2008ZX10002-005)；天津市卫生局重点攻关资助项目(07KG9)；

详细信息

中图分类号: R735.7
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出版历程
- 出版日期: 2011-04-20

Serum thymosin β4 level in patients with hepatocellular carcinoma

Research funding:

摘要

摘要: 目的检测肝细胞癌（HCC）患者血清胸腺素β4（Tβ4）水平及其影响因素。方法采用ELISA方法检测80例HCC患者血清Tβ4水平,并与40例健康人及30例肝硬化患者比较。同时比较不同肿瘤情况及肝功能对HCC组患者血清Tβ4浓度的影响。结果 HCC患者及肝硬化患者血清Tβ4水平均低于健康人,差异有统计学意义（χ2=81.228,P<0.001）。按照BCLC分期或CLIP分期将HCC患者分别分为4个或6个亚组,血清Tβ4浓度差异均有统计学意义（χ2=8.669～13.675,P<0.034）。HCC患者中有肝内转移组血清Tβ4浓度高于无肝内转移组,差异有统计学意义（Z=2.264,P=0.024）;有门脉瘤栓组血清Tβ4浓度高于无门脉瘤栓组,差异有统计学意义（Z=2.574,P=0.010）。无肝内转移而且无远处转移的HCC患者按照肝功能Child-Pugh评分分为A、B、C级3组,血清Tβ4浓度差异有统计学意义（χ2=6.467,P=0.039）。结论肝细胞癌患者血清Tβ4浓度低于健康人,且肝功能越差,血清Tβ4浓度越低。而发生肝内转移或门脉瘤栓的患者血清Tβ4浓度高于未发...
- 癌,肝细胞 /
- 胸腺素
Abstract: Objective To investigate serum thymosin β4 (Tβ4) level in patients with hepatocellular carcinoma (HCC) .Methods Serum Tβ4 level were measured in 80 patients with HCC, 40 patients with cirrhosis and 40 healthy controls.Serum Tβ4 level were measured by enzyme-linked immunosorbent assay (ELISA) .Level of serum Tβ4 in different stages of HCC were compared.Patients with HCC were divided into groups according with or without interhepatic metastasis, portal vein tumor thrombus and distant metastasis and then compared.Results Compared with that in healthy controls, serum Tβ4 level in patients with HCC and cirrhosis was lower with statistically significant difference (χ2=81.228, P<0.001) .Patients with HCC had divided into group A, B, C and D according their BCLC stage.Level of Tβ4 in these 4 groups was statistically significant difference (χ2=8.669, P=0.034) .Patients with HCC were divided into group 0, 1, 2, 3, 4 and 5 according CLIP score.Level of Tβ4 in these 6 groups had statistically significant difference (χ2=13.675, P=0.018) .Meanwhile, Patients with HCC were also divided according interhepatic metastasis, portal vein tumor thrombus and distant metastasis.Serum Tβ4 level was higher in patients with interhepatic metastasis than that in those without metastasis (Z=2.264, P=0.024) .Serum Tβ4 level was higher in patients with portal vein tumor thrombus than that in those without tumor thrombus (Z=2.574, P=0.010) .Patients who developed neither portal vein tumor thrombus nor distant metastasis were divided into group A, B and C according Child-pugh grade and there was statistically significant difference (χ2=6.467, P=0.039) .Conclusion Serum Tβ4 level in patients with HCC were lower than that in healthy controls.And serum Tβ4 level in patients with interhepatic metastasis or portal vein tumor thrombus was higher than that in patients without those diseases.
- carcinoma /
- hepatocellular

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参考文献(16)

[1]Low TL, Goldstein AL.Chemical characterization of thymosinbeta 4[J].J Biol Chem, 1982, 257 (2) :1000-1006.

[2]Xu GJ, Hannappel E.Determination of thymosin beta 4 byperitoneal macrophages and adherent spleen cells[J].ProcNatl Acad Sci, 1982, 79 (13) :4006-4009.

[3]Han T, Liu Y, Liu H, et al.Serum thymosinβ4 level inpatient with hepatitis B virus-related liver failure[J].World JGastroenterol, 2010, 16 (5) :625-630.

[4]Bruix J, Sherman M.Management of hepatocellularcarcinoma[J].Hepatology, 2005, 42 (5) :1208-1236.

[5]Llovet JM, Bru C, Bruix J.Prognosis of hepatocellularcarcinoma:the BCLC staging classification[J].Semin LiverDis, 1999, 19 (3) :329-338.

[6]Llovet JM, Burroughs A, Bruix J.Hepatocellular carcinoma[J].Lancet, 2003, 362 (9399) :1907-1917.

[7]The Cancer of the Liver Italian Program (CLIP) investigators.Prospective validation of the CLIP score:a new prognosticsystem for patients with cirrhosis and hepatocellularcarcinoma[J].Hepatology, 2000, 31 (4) :840-845.

[8]Carlier MF, Didry D, Erk I, et al.Tbeta 4 is not a simple G-actinsequestering protein and interacts with F-actin at highconcentration[J].J Biol Chem, 1996, 271 (16) :9231-9239.

[9]Philp D, Badamchian M, Scheremeta B, et al.Thymosin beta 4and a synthetic peptide containing its actin-binding domainpromote dermal wound repaire in db/db diabetic mice and inaged mice[J].Wound Repair Regen, 2003, 11 (1) :19-24.

[10]Bock-Marqutte I, Saxena A, White MD, et al.Thymosin beta4 activates integrin-linked kinase and promotes cardiaccell migration, survival and cardiac repair[J].Nature, 2004, 432 (7016) :466-472.

[11]Sosne G, Qiu P, Christopherson PL, et al.Thymosin beta4suppression of corneal NFκB:a potential anti-inflammatorypathway[J].Exp Eye Res, 2007, 84 (4) :663-669.

[12]Cha HJ, Jeong MJ, Kleinman HK.Role of thymosinβ4 intumor metastasis and angiogenesis[J].J Natl Cancer Inst, 2003, 95 (22) :1674-1680.

[13]Mai I, Kazuhiro I, Shigeyuki U, et al.Overexpression of thymosinβ4 increases pseudopodia formation in LNCaP prostatecancer cells[J].Biol Pharm Bull, 2009, 32 (6) :1101-1104.

[14]Wang WS, Chen PM, Hsiao HL, et al.Overexpression ofthe thymosin beta 4 gene is associated with malignantprogression of SW480 colon cancer cells[J].Oncogene, 2003, 22 (21) :3297-3306.

[15]Barnaeva E, Nadezhda A, Hannappel E, et al.Thymosin beta4upregulates the expression of hepatocyte growth factor anddownregulate the expression of PDGF-beta receptor in humanhepatic stellate cells[J].Ann N Y Acad Sci, 2007, 1112:154-160.

[16]Hsiao HL, Wang WS, Chen PM, et al.Overexpression of thymosinbeta-4 renders SW480 colon carcinoma cells more resistant toapoptosis triggered by FasL and two topoisomeraseⅡinhibitorsvia downregulating Fas and upregulating Survivin expression, respectively[J].Carcinogenesis, 2006, 27 (5) :936-944.

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