中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R

留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

非酒精性脂肪性肝炎相关肝细胞癌111例临床荟萃分析

段晓燕 范建高

引用本文:
Citation:

非酒精性脂肪性肝炎相关肝细胞癌111例临床荟萃分析

详细信息
  • 中图分类号: R735.7

Meta-analysis of 111 patients with nonalcoholic steatohepatitis-associated hepatocellular carcinoma

  • 摘要: 目的总结非酒精性脂肪性肝炎(NASH)基础上肝癌的临床特征。方法对以"fatty liver、NASH、liver cancer、HCC"等为关键词,在Pubmed、Medline、OVID数据库检索得到的1990至2010年发表的22篇文献中111例NASH基础上肝癌患者的临床资料进行汇总分析。结果 (1)发现肝功能异常的年龄为60岁,诊断NASH的年龄为63.9岁,诊断肝细胞癌(HCC)的年龄66.7岁;(2)男性占62%,男女之比1.64:1;(3)79%患者伴有肥胖,78%伴有糖尿病,33%伴有血脂异常,52%伴有高血压;(4)71%患者肿瘤为单发,肿瘤直径最小1.0 cm,最大13 cm(平均3.3 cm);(5)大多数肿瘤发生在肝右叶;(6)67%HCC伴肝硬化,肿瘤组织以梁索型居多,分化程度多为良好~中分化;(7)多数患者无任何症状,常规体检时发现肿瘤;(8)65%病例AFP和/或PIVKAII升高;(9)大多数病例经手术切除治疗,术后平均随访24个月,21%患者死亡,15%复发。结论 NASH基础上HCC多见于男性,这类患者往往伴有代谢性疾病,尽管肿瘤分化程度较高,根治...

     

  • [1]Powell EE, Cooksley WG, Hanson R, et al.The naturalhistory of nonalcoholic steatohepatitis:a follow-up study offorty-two patients for up to 21 years[J].Hepatology, 1990, 11 (1) :74-80.
    [2]Cotrim HP, ParanáR, Braga E, et al.Nonalcoholicsteatohepatitis and hepatocellular carcinoma:naturalhistory?[J].Am J Gastroenterol, 2000, 95 (10) :3018-3019.
    [3]Zen Y, Katayanagi K, Tsuneyama K, et al.Hepatocellularcarcinoma arising in non-alcoholic steatohepatitis[J].PatholInt, 2001, 51 (2) :127-131.
    [4]Orikasa H, Ohyama R, Tsuka N, et al.Lipid-rich clear-cell hepatocellular carcinoma arising in non-alcoholicsteatohepatitis in a patient with diabetes mellitus[J].JSubmicrosc Cytol Pathol, 2001, 33 (1-2) :195-200.
    [5]Shimada M, Hashimoto E, Taniai M, et al.Hepatocellularcarcinoma in patients with non-alcoholic steatohepatitis[J].J Hepatol, 2002, 37 (1) :154-160.
    [6]Yoshioka Y, Hashimoto E, Yatsuji S, et al.Nonalcoholicsteatohepatitis:cirrhosis, hepatocellular carcinoma, and burnt-out NASH[J].J Gastroenterol, 2004, 39 (12) :1215-1218.
    [7]Bencheqroun R, Duvoux C, Luciani A, et al.Hepatocellularcarcinoma without cirrhosis in a patient with nonalcoholicsteatohepatitis[J].Gastroenterol Clin Biol, 2004, 28 (5) :497-499.
    [8]Mori S, Yamasaki T, Sakaida I, et al.Hepatocellular carcinomawith nonalcoholic steatohepatitis[J].J Gastroenterol, 2004, 39 (4) :391-396.
    [9]Bullock RE, Zaitoun AM, Aithal GP, et al.Association of non-alcoholic steatohepatitis without significant fibrosis withhepatocellular carcinoma[J].J Hepatol, 2004, 41 (4) :685-690.
    [10]Cuadrado A, Orive A, García-Suárez C, et al.Non-alcoholic steatohepatitis (NASH) and hepatocellularcarcinoma[J].Obes Surg, 2005, 15 (3) :442-446.
    [11]Sato K, Ueda Y, Ueno K.Hepatocellular carcinoma andnonalcoholic steatohepatitis developing during long-termadministration of valproic acid[J].Virchows Arch, 2005, 447 (6) :996-999.
    [12]Ikeda H, Suzuki M, Takahashi H, et al.Hepatocellularcarcinoma with silent and cirrhotic non-alcoholicsteatohepatitis, accompanying ectopic liver tissue attachedto gallbladder[J].Pathol Int, 2006, 56 (1) :40-45.
    [13]Hai S, Kubo S, Shuto T.Hepatocellular carcinoma arisingfrom nonalcoholic steatohepatitis:report of two cases[J].Surg Today, 2006, 36 (4) :390-394.
    [14]Ichikawa T, Yanagi K, Motoyoshi Y, et al.Two cases of non-alcoholic steatohepatitis with development of hepatocellularcarcinoma without cirrhosis[J].J Gastroenterol Hepatol, 2006, 21 (12) :1865-1866.
    [15]Tsutsumi K, Nakayama H, Sakai Y, et al.Two cases ofpatients with hepatocellular carcinoma (HCC) that developedin cryptogenic cirrhosis suggestive of nonalcoholicsteatohepatitis (NASH) as background liver disease afterclinical courses of 26 years[J].Nippon Shokakibyo GakkaiZasshi, 2007, 104 (5) :690-697.
    [16]Hashizume H, Sato K, Takagi H, et al.Primary liver cancerswith nonalcoholic steatohepatitis[J].Eur J GastroenterolHepatol, 2007, 19 (10) :827-834.
    [17]Maeda T, Hashimoto K, Kihara Y, et al.Surgically resectedhepatocellular carcinomas in patients with non-alcoholicsteatohepatitis[J].Hepatogastroenterology, 2008, 55 (85) :1404-1406.
    [18]Hashimoto E, Yatsuji S, Tobari M, et al.Hepatocellularcarcinoma in patients with nonalcoholic steatohepatitis[J].JGastroenterol 2009, 44 (Suppl 19) :89-95.
    [19]Kawada N, Imanaka K, Kawaguchi T, et al.Hepatocellularcarcinoma arising from non-cirrhotic nonalcoholicsteatohepatitis[J].J Gastroenterol, 2009, 44 (12) :1190-1194.
    [20]Malik SM, Gupte PA, de Vera ME, et al.Liver transplantationin patients with nonalcoholic steatohepatitis relatedhepatocellular carcinoma[J].Clin Gastroenterol Hepatol, 2009, 7 (7) :800-806.
    [21]Chagas AL, Kikuchi LO, Oliveira CP, et al.Doeshepatocellular carcinoma in non-alcoholic steatohepatitisexist in cirrhotic and noncirrhotic patients?[J].Braz J MedBiol Res, 2009, 42 (10) :958-962.
    [22]Takuma Y, Nouso K.Nonalcoholic steatohepatitis-associated hepatocellular carcinoma:Our caseseries and literature review[J].World J Gastroenterol, 2010, 16 (12) :1436-1441.
    [23]Hagymási K, Tulassay Z.Epidemiology, risk factors andmolecular pathogenesis of primary liver cancer[J].Orv Hetil, 2008, 149 (12) :541-548.
    [24]Bugianesi E.Non-alcoholic steatohepatitis and cancer[M].Clin Liver Dis, 2007:191-207.
    [25]Bugianesi E.Review article:steatosis, the metabolicsyndrome and cancer[J].Aliment Pharmacol Ther, 2005, 22 (Suppl 2) :40-43.
    [26]Caldwell SH, Oelsner DH, Iezzoni J, et al.Cryptogeniccirrhosis:clinical characterization and risk factors forunderlying disease[J].Hepatology, 1999, 29 (3) :664-669.
    [27] Cuadrado A, Orive A, García-Suárez C, et al.Non-alcoholic steatohepatitis (NASH) and hepatocellularcarcinoma[J].Obes Surg, 2005, 15 (3) :442-446.
    [28]Ascha MS, Hanouneh IA, Lopez R, et al.The incidenceand risk factors of hepatocellular carcinoma in patientswith nonalcoholic steatohepatitis[J].Hepatology, 2010, 51 (6) :1972-1978.
    [29]Hashimoto E, Taniai M, Kaneda H, et al.Comparison ofhepatocellular carcinoma patients with alcoholic liverdisease and nonalcoholic steatohepatitis[J].Alcohol ClinExp Res, 2004, 28 (suppl s2) :164-168S.
    [30]Page JM, Harrison SA.NASH and HCC[J].Clin Liver Dis, 2009, 13 (4) :631-647.
    [31]Evert M, Dombrowski F.Hepatocellular carcinoma in thenon-cirrhotic liver[J].Pathologe, 2008, 29 (1) :47-52.
  • 加载中
计量
  • 文章访问数:  22965
  • HTML全文浏览量:  457
  • PDF下载量:  1559
  • 被引次数: 0
出版历程
  • 出版日期:  2011-04-20
  • 分享
  • 用微信扫码二维码

    分享至好友和朋友圈

目录

    /

    返回文章
    返回