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肝纤维化治疗新策略

钟巍 谢渭芬

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肝纤维化治疗新策略

详细信息
  • 中图分类号: R575.2

New strategy for the treatment of hepatic fibrosis

  • 摘要: 肝纤维化是各种慢性肝病共有的病理改变,逆转肝纤维化可阻止大多数慢性肝病进展。肝星状细胞(HSC)活化是肝纤维化发生的中心环节,故传统治疗策略大多以HSC为治疗靶点,并在动物实验取得良好疗效。但最近研究发现活化HSC也可促进肝细胞再生和肝脏损伤修复。肝细胞核因子是一组对肝细胞分化和功能维持起关键作用的转录因子,既可减少细胞外基质(ECM)分泌,又可促进肝细胞再生,保护肝细胞功能。促进肝细胞核因子表达是治疗肝纤维化更为理想的策略。

     

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  • 出版日期:  2011-03-20
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