PDF下载 ( 2523 KB)
The clinical analysis of hepatic dysfunction caused by hemophagocytic syndrome of 10 cases
-
摘要: 目的通过对10例以肝功能异常为主要临床表现的噬血细胞综合征病例进行分析,探讨本病的临床特点,提高对本病的认识。方法对10例患者的病史、临床表现和实验室检查结果进行综合分析。结果噬血细胞综合征(HPS)可表现为严重的肝功能损害,其特点为胆红素明显升高,以直接胆红素升高为主,以及ALT、AST及GGT升高。结论不明原因肝功能异常并伴有发热和血细胞减少的患者应警惕HPS,早期诊断和治疗。
-
关键词:
- 淋巴组织细胞增多症,嗜血细胞性 /
- 肝功能试验
Abstract: Objective To investigate the clinical features of hepatic dysfunction caused by hemophagocytic syndrome (HPS) .Methods Medical records, clinical manifestations and laboratory findings were analyzed.Results Characteristics of hepatic dysfunction caused by hemophagocytic syndrome were increase of direct bilirubin level, and increase of alanine aminotransferase (ALT) , aspartate aminotransferase (AST) and γ-glutamyltransferase (GGT) .Conclusion Awareness of diagnosis of HPS is crucial when patients have unknown hepatic dysfunction, fever, hepatosplenomegaly and pancytopenia.-
Key words:
- lymphohistiocytosis /
- hemophagocytic
-
[1]Henter JI.HLH-2004:Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis[J].Pediatr Blood Cancer, 2007, 48 (2) :124-131. [2]Janka G, zui Stadt V.Familial and Acquired Hemoph-agocytic Lymphohistiocytosis[A].Hematology Am Soc Hemotol Educ Program, 2005:82-88. [3]Henter JI, Elinder G, Soder O, et al.Incidence in Sweden and clinical features of familial hemophagocytic lymphohistiocytosis[J].Acta Paediatr Scand, 1991, 80 (4) :428-435. [4]Chandra P, Chaudhery SA, Rosener F, et al.Transient histocytosis with striking phagocytosis of platelets, leukocytes and erythrocytes[J].Arch Intern Med, 1975, 135 (7) :989-991. [5]Janka GE.Familial and acquired hemophagocytic lymphohistiocytosis[J].Eur J Pediatr, 2007, 166 (2) :95-109. [6]王昭, 王旖旎, 冯翠翠, 等.NK细胞活性和血清可溶性CD25在继发性噬血细胞性淋巴组织细胞增多症的诊断意义[J].中国实验血液学杂志, 2008, 16 (5) :1154-1157. [7]王旖旎, 王昭, 王晶石, 等.糖化铁蛋白在诊断获得性噬血细胞性淋巴组织细胞增多症中意义的探讨[J].中国实验血液学杂志, 2008, 16 (6) :1379-1382. -
本文二维码
计量
- 文章访问数: 3804
- HTML全文浏览量: 21
- PDF下载量: 1041
- 被引次数: 0
下载:
