Abstract: Objective To study the characteristics and relationship of the biochemistry and pathology of the ischemic hepatitis patients and improve diagnostic ability.Methods A retrospective analysis was performed in 45 patients with IH and liver biopsy was performed in 9 patients.Results Average serum ALT,AST and LDH level was significantly elevated while γ-GT,AKP and TBil was within the normal range in IH.With the prolongation of ischemic time,the value of ALT and AST tend to rise.It is higher in patients with ischemic time for 6-12 h or >12 h than those with ischemic time<6 h.There is statistically-significant difference between the groups.In additional,liver function can be improved with treatment.Average serum LDH value was higher in patient with cardiac ischemic hepatitis than hypovolemic ischemic hepatitis.There is no statistically-significant difference in biochemistry between the different pathological grading.Pathohistological changes in patient with IH was slight.Conclusion Biochemical change is obvious while pathological change is slight,showing their inconsistency with each other.Pathohistogical change and the etiology of IH are the possible explanation for biochemical change and prognosis.We can conclude that the key to successful treatment is to treat the primary disorder and improve the liver microcirculation.