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The change in serum thyroid hormone levels in acute hepatitis B
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摘要: 目的研究急性乙型肝炎患者血清中甲状腺激素水平变化情况,观察患者甲状腺激素水平的动态变化和甲状腺激素水平异常与发病时间的关系。方法急性乙型肝炎患者36例作为观察对象,健康体检的36人作为对照组。检测其入院时的甲状腺激素水平:血清总甲状腺素(TT4)、血清总三碘甲腺原氨酸(TT3)、血清游离甲状腺素(FT4)、血清游离三碘甲腺原氨酸(FT3)、促甲状腺激素(TSH),并与对照组比较。对异常者1周后复查甲状腺激素水平,以后每周复查1次,直至正常,观察其动态变化。结果急性乙型肝炎患者血清甲状腺激素TT4、TT3、FT4、FT3水平较对照组增高,差异具有统计学意义(P<0.05)。TSH较对照组降低,但TSH均在正常值范围内,差异无统计学意义(P>0.05)。入院时TT4、TT3、FT4、FT3高于正常值者在第三周全部转为正常。结论急性乙型肝炎患者血清甲状腺激素TT4、TT3、FT4、FT3水平升高,对于升高超过正常值者不需要治疗,随着肝功能逐渐好转,短期可恢复正常。Abstract: Objective To investigate the dynamic changes in thyroid hormone levels in the patients with acute hepatitis B and determine the relationship between the abnormal thyroid hormone levels and onset time.Methods 36 patients with acute hepatitis B and 36 healthy controls were assigned for observation.At admission,thyroid hormone levels including serum total thyroxine(TT4),serum total triiodothyronine(TT3),serum free thyroxine(FT4),serum free triiodothyronine(FT3) and thyroid-stimulating hormone(TSH) were tested and compared with those of controls.Check-up was performed at 1 week after admission in patients with abnormal thyroid hormone levels and then was performed per week until normality.The dynamic change of thyroid hormone levels was recorded.Results The levels of TT4,TT3,FT4,FT3 in patients with acute hepatitis B were higher than those in the control group,P<0.05.There was significant difference between the two groups.The TSH value remained within the normal range.The increased serum thyroid hormone levels has returned to normal limits within 3 weeks.Conclusion The patients of acute hepatitis B whose serum thyroid hormone(TT4,TT3,FT4,FT3) levels are higher than normal person do not need treatment and gradually returns to normal with the improvement of the liver.
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Key words:
- hepatitis B /
- thyroid hormones
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