PDF下载 ( 2487 KB)
Treatment of hepatic encephalopathy and minimal hepatic encephalopathy with L-ornitine-L-aspartate
-
摘要:
检索2000年至2010年期间在国内外发表的有关门冬氨酸鸟氨酸治疗显性肝性脑病(HE)和轻微型肝性脑病(MHE)的文献,并进行分析综述。结果显示,门冬氨酸鸟氨酸的治疗机制是直接降低血氨,疗效可靠,无明显不良反应,其对显性HE的疗效已得到公认,对MHE的疗效也在国内外研究中得到初步证实。
Abstract:The domestic and oversea literature on the treatment of hepatic encephalopathy (HE) and minimal hepatic encephalopathy (MHE) with L-ornitine-L-aspartate between 2000 and 2010 were searched and summarized.The results showed that mechanism of the therapy was direct reduction of blood ammonia level.The efficacy and safety of L-ornitine-L-aspartate in the treatment of HE was well recognized and its effect on MHE was primarily accepted.
-
Key words:
- hepatic encephalopathy /
- aspartic acid /
- ornithine
-
[1]肝性脑病诊断治疗专家委员会.肝性脑病诊断治疗专家共识[J].中华实验和临床感染病杂志, 2009, 3 (4) :449-473. [2]Rikkers L, Jenko P, Rudman D, et al.Subclinical hepatic encephalopathy:detection, prevalence and relationship to nitrogen metabolism[J].Gastroenterology, 1978, 75 (3) :462-469. [3]Ferenci P, Lockwork A, Mullen, et al.Hepatic encephalopathy:definition, nomenclature, diagnosis and quanitification:final report of the working party at the 11th World Congress of Gastroenterology.Vienna 1998[J].Hepatology, 2002, 35 (3) :716-721. [4]李瑜元, 聂玉强, 沙卫红, 等.亚临床型肝性脑病的发病率调查[J].中华内科杂志, 2000, 39 (9) :625-626. [5]McPhail MJ, Bajaj JS, Thomas HC, et al.Pathogenesis and diagnosis of hepatic encephalopathy[J].Expert Rev Gastroenterol Hepatol.2010, 4 (3) :365-378. [6]Bass NM.Review article:the current pharmacological therapies for hepatic encephalopathy[J].Aliment Pharmacol Ther, 2007, 25 (Suppl 1) :23-31. [7]De Soarez PC, Oliveira AC, Padovan J, et al.A critical analysis of studies assessing L-ornithine-L-aspartate (LOLA) in hepatic encephalopathy treatment[J].Arq Gastroenterol, 2009, 46 (3) :241-247. [8]Jiang Q, Jiang XH, Zheng MH, et al.L-Ornithine-l-aspartate in the management of hepatic encephalopathy:a meta-analysis[J].J Gastroenterol Hepatol, 2009, 24 (1) :9-14. [9]曾峥, 李瑜元.乳果糖干预治疗对亚临床肝性脑病病程的影响[J].中华医学杂志, 2003, 83 (13) :1126-1129. [10]刘冠军, 王合群, 王良超.门冬氨酸鸟氨酸治疗肝性脑病55例疗效观察[J].临床医学, 2010, 30 (6) :60-61. [11]周莹群, 陈世耀, 郭传勇等.左旋门冬氨酸鸟氨酸治疗亚临床肝性脑病的生命质量研究[J].胃肠病学和肝病学杂志, 2009, 18 (1) :48-51. -
本文二维码
计量
- 文章访问数: 4367
- HTML全文浏览量: 30
- PDF下载量: 1479
- 被引次数: 0
下载:
