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The therapeutic effect of ursodeoxycholic acid capsules in patients with primary biliary cirrhosis
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摘要: 目的探讨熊去氧胆酸(优思弗)在治疗原发性胆汁性肝硬化中的作用。方法选择原发性胆汁性肝硬化患者60例,随机分成治疗组和对照组。所有研究对象在继续行护肝及支持治疗的基础上,治疗组给予优思弗口服。用法用量:按体重每日10 mg/kg。体重60 kg,每日剂量2粒,早晚各1粒;体重80 kg,每日剂量3粒,早、中、晚各1粒;体重100 kg,每日剂量4粒,早、中各1粒,晚2粒。对照组给予熊去氧胆酸片(国产)每日8～10 mg/kg,早晚进餐时分次给予。治疗均为26周。结果全部患者完成26周治疗。治疗组患者肝功能指标中的ALT、GGT、TBil的改善均明显高于对照组(P<0.01);治疗组治疗皮肤瘙痒及乏力的有效率明显高于对照组(P<0.05)。结论与熊去氧胆酸片(国产)相比,优思弗可以快速、有效地改善肝功能各项酶学指标,治疗皮肤瘙痒及乏力的有效率高,可作为原发性胆汁性肝硬化患者的首选药物治疗。Abstract: Objective To determine the therapeutic effect of ursodeoxycholic acid capsules in patients with primary biliary cirrhosis.Methods Sixty patients of primary biliary cirrhosis were randomly divided into treatment group and control group.Liver protection and supportive treatment were given for the two groups.Ursodeoxycholic acid capsules (10mg/kg daily) was given for the treatment group (Usage and dosage: for 60kg Weight, two times a day, 1 grain in the morning and evening;for 80kg weight, three times a day, 1 grain in the morning, noon and evening;for 100kg weight, three times a day, 1 grain in the morning and noon, and 2 grains in the evening) .Ursodeoxycholic acid tablets (made in china) 8-10mg/Kg daily was given for the control group.The treatment duration was 26 weeks in both groups.Results Alanine aminotransferase (ALT) , γ-glutamyl transferase (GGT) and serum total bilirubin (TBIL) were significantly improved in the treatment group than the control group (P<0.01) .The skin itching and fatigue situations were also improved in treatment group than the control group (P<0.05) .Conclusion Compared with ursodeoxycholic acid tablets, ursodeoxycholic acid capsules can quickly and effectively reduce the skin itching and fatigue in primary biliary cirrhosis, and improve liver function indexes.
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Key words:
- liver cirrhosis /
- biliary /
- autoimmune diseases
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[1]Beuers U.Drug Insight:mechanisims and sites of action of ursode-oxycholic acid in cholestasis[J].Nature Clinical Practice Gastroen-terology and Hepatology, 2006, 3 (6) ∶318-328. [2]Mitsuyoshi H, Nakashima T, Sumida Y, et al.Ursodeoxycholic acidprotects hepatocytes against osidative injury via induction of antioxida-nts[J].Biochem Biophys Res Commun, 1999, 263 (2) ∶537-542. [3]Von Ritter C, Sreejayan N, Müller I, et al.Ursodeoxycholic acid re-duces lipid peroxidation and mucin secretagougue activity of humanbile in cholesterol Gallstone disease[J].Gastroenterology, 1998, 114 (4) ∶A548-A549. -
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