HLA-DRB1*14和*15等位基因与肝癌的相关性

黄爱春; 吴继周; 吴健林; 陈务卿; 韦颖华; 罗双艳; 宁秋悦; 李兰兰

HLA-DRB114和15等位基因与肝癌的相关性

广西医科大学第一附属医院感染性疾病科

基金项目:

国家自然科学基金(项目批准号:30960170)；广西壮族自治区卫生厅课题(合同号:Z2006048)；

详细信息

中图分类号: R735.7
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出版历程
- 出版日期: 2010-04-20

The correlation between HLA-DRB114 and HLA-DRB115 alleles and hepatocellular carcinoma

Research funding:

摘要

摘要: 目的探讨HLA-DRB1*14和*15等位基因与肝癌发生的相关性。方法以40例原发性肝癌患者作为病例组,以135例健康人作为对照组,应用PCR-SSP方法对研究对象外周血的HLA-DRB1等位基因进行检测,分析其表达与原发性肝癌的相关性。结果 HLA-DRB1*14在病例组中的分布频率较对照组显著增高（χ2=9.925,P=0.002,OR=3.450,95%CI:1.555～7.655）,HLA-DRB1*15在病例组和对照组中的分布频率的差异无统计学意义（χ2=1.260,P=0.262,OR=1.538,95%CI:0.723～3.274）。结论 HLA-DRB1*14可能是原发性肝癌的易感基因,HLA-DRB1*15可能与原发性肝癌的发生无明显关系。
- 等位基因 /
- 肝肿瘤 /
- HLA-DR抗原
Abstract: Objective To study the relationship between HLA-DRB1*14 and HLA-DRB1*15 genes and hepatocellular carcinoma.Methods 40 patients with hepatocellular carcinoma and 135 healthy controls were included in the study.HLA-DRB1 genes were detected by PCR-SSP.Results The frequency of HLA-DRB1*14 was significantly higher than the control group (χ2=9.925, P=0.002, OR=3.450, 95%CI:1.555～7.655) , however, no significant difference was found in HLA-DRB1*15 frequency between the two groups (χ2=1.260, P=0.262, OR=1.538, 95%CI:0.723～3.274) .Conclusion HLA-DRB1*14 might be the responsible gene for the development of hepatocellular carcinoma with a minor effect by HLA-DRB1*15 genes.
- alleles /
- liver neoplasms /
- HLA-DR antigens

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参考文献(9)

[1]蔡琳, 易应南.福建省原发性肝癌遗传因素分析[J].中国公共卫生学报, 1997, 16 (6) ∶335-337.

[2]Bunee MO, Neil CM, Barnard MC, et a1.Phototyping eomprehensiveDNA typing for HLA-A, B, C, DRB1, DRB3, DRB4, DRB5&DOB1by PCR with144 primer mixes utilizing sequence specific Prim-ers (PCR-SSP) [J].Tissue Antigens, 1995, 46 (5) ∶355-367.

[3]龚非力, 沈关心, 李卓娅, 等.医学免疫学[M].第2版.北京:科学出版社, 2004∶116-131.

[4]Davis MM, Bjorkman PJ.T cell antigen receptor genes and T cellrecognition[J].Nature, 1998, 334 (6181) ∶395-398.

[5]Jackson MR, Cohen DMF, Peterson PA, et a1.Regulation of MHCClass I transport by the molecular chaperone calnexin[J].Science, 1994, 263 (5145) ∶384-387.

[6]Donaldson PT, Ho S, Williams R, et a1.HLA class lI alleles in Chi-nese patients with hepatoeellular carcinoma[J].Liver, 2001, 21 (2) ∶143-148.

[7]El-Chennawi FA, Auf FA, Metwally SS, et al.HLA-Class II Al-leles in Egyptian Patients with Hepatocellular Carcinoma[J].Immu-nol Invest, 2008, 37 (7) ∶661-674.

[8]Yuan JH, Cui M, Sun CG, et al.Association between HLA-DRB1*1201/*1501 and different stages of HBV infection[J].J ShandongUniversity, 2005, 43 (5) ∶428-431.

[9]蒋业贵, 王宇明.HLA复合体与乙型肝炎的关系[J].世界华人消化杂志, 2000, 8 (10) ∶1150-1153.

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