转化生长因子β与肝纤维化的研究

齐晓艳; 陈新华

转化生长因子β与肝纤维化的研究

内蒙古医学院附属人民医院

基金项目:

内蒙古自治区高等学校科学研究项目(NJ09114)；

详细信息

中图分类号: R575.2
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出版历程
- 出版日期: 2010-02-20

Study on transforming growth factor β and liver fibrosis

Research funding:

摘要

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参考文献(17)

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[9]Bissell DM, Roulot D, George J.Transforming growth factor b and the liver[J].Hepatology, 2001, 34:859-867.

[10]Moustakas A, Pardali K, Gaal A, et al.Mechanisms of TGF-βsignalling in regulation of cell growth and differentiation[J].Immu-nolLett, 2002, 82 (1-2) :85-91.

[11]卢平, 周力, 张永宏.转化生长因子β1-Smads信号传导与肝纤维化的关系[J].临床肝胆病杂志, 2006, 22 (1) :69-71.

[12]高春芳.转化生长因子β1与肝纤维化[J].中华医学杂志, 2005, 85 (15) :1074-1077.

[13]JIANG Wei, YANG Chang-qing, LIUWen-bin, et al, Blockage of transforming growth factor receptors prevents progression of pig serum-induced rat liver fibrosis[J].World Gastroenterol, 2004, 10 (11) :1634-1638.

[14]XUXin-bao, LENG Xi-sheng, HE Zhen-ping et al.Inhibitory effect of retroviral vector containing anti-sense Smad4gene on Ito cell line, LI90[J].Chinese Medical Journal, 2004, 117 (8) :1170-1177.

[15]Wan M, Tang Y, Tytler EM, et al.Smad4protein stability is regula-ted by ubiquittin ligase SCF beta-TrCP1[J].Biol Chem, 2004, 279 (15) :14484-14487.

[16]Gressner R, Weiskirchen.Modern pathogenetic concept of fibrosis suggest stellate cells and TGF-b as major players and therapeutic targets[J].Cell Mol Med, 2006, 110 (1) :76-99.

[17]Dooley S, Hamzavi J, Breitkopf K, et al.Smad7prevents activation of hepatic stellate cells and liver fibrosis in rats[J].Gastroenterology, 2003, 125 (1) :178-191.

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