原发性肝癌患者血清VEGF、TGF-β1表达水平与浸润转移关系的研究

孙屹峰; 张超贤; 秦咏梅

原发性肝癌患者血清VEGF、TGF-β1表达水平与浸润转移关系的研究

新乡医学院第一附属医院

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中图分类号: R735.7
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出版历程
- 出版日期: 2010-02-20

The Serum Levels of VEGF and TGF-β1 in Patients with Primary Hepatic Carcinoma

摘要

摘要: 目的探讨原发性肝癌患者血清血管内皮生长因子（VEGF）及转化生长因子-β1（TGF-β1）的表达水平与肝癌浸润和转移的相关性。方法采集98例原发性肝癌患者和4O例健康志愿者的血清。应用ELISA法检测受检者血清VEGF、TGF-β1的表达水平,并分析其与临床病理因素之间的关系。结果原发性肝癌患者血清VEGF与TGF-β1水平显著高于正常对照组（P<0.01）,患者血清VEGF、TGF-β1的表达水平与患者与肿瘤的组织学分级、浸润深度、转移密切相关（P<0.01）。血清VEGF与TGF-β1水平呈显著正相关（r=0.418,P<0.01）。结论VEGF和TGF-β1与原发性肝癌的病情发展、浸润和转移有密切相关性,临床上,血清VEGF、TGF-β1的表达水平可作为了解原发性肝癌生物学行为和判断预后的指标。
- 血管内皮生长因子 /
- 转化生长因子-β1 /
- 原发性肝癌 /
- 血清 /
- 浸润 /
- 转移
Abstract: Objective To evaluate the relationship between serum levels of vascular endothelial growth factor (VEGF) and transforming growth factor-β1 (TGF-β1) with the development, invasion and metastasis of primary hepatic carcinoma (PHC) .Methods Serum samples were collected from 98 patients with PHC and 40 healthy controls.The expression of serum VEGF and TGF-β1 were measured by ELISA and their relationship to clinical parameters were analyzed.Results The serum levels of VEGF and TGF-β1 were significantly increased and correlated with tumor differentiation, invasion and metastasis in PHC patients compared to the healthy controls (P<0.05) .VEGF was positively correlated with TGF-β1.Conclusion Serum levels of VEGF and TGF-β1 are closely correlated with invasion and metastasis of PHC.Therefore, their expression in serum might be a useful tool for the evaluation of the biological behavior and prognosis of PHC.
- vascular endothelial growth factor /
- transforming growth factor-β1 /
- primary hepatic carcinoma /
- serum /
- invasion /
- metastasis

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参考文献(12)

[1]黄明哲, 费哲为, 张一楚.胃癌患者血管内皮生长因子和肿瘤坏死因子的水平及其意义[J].上海医学, 2006, 29 (5) :290-292.

[2]Harlozinska A.Progress in molecular mechanisms of tumor metastasis and angiogenesis[J].Anticancer Res, 2005, 25 (5) :3327-3333.

[3]SALVEN P, ORPANA A, JOENSUU H.Leukocytes and platelets of patients with cancer contain high levels of vascular endothelial growth factor[J].Clin Cancer Res, 1999, 5 (3) :487-491.

[4]梁启廉, 陈小东, 王三明, 等.血管内皮生长因子和抑癌基因P33ING1与胃癌生物学行为的关系[J].第四军医大学学报, 2007, 28 (2) ;175-178.

[5]肖业臣, 黄亚东, 李校, 等.肿瘤中TGF-β1/Smads信号传导通路的研究进展[J].肿瘤防治研究, 2006, 33 (8) :616-618.

[6]Bollard CM, Rossing C, Calonge MJ, et al.Adapting a transforming growth factor beta related tumor protection strategy to enhance antitu-mor immunity[J].Blood, 2002, 99 (9) :3179-3187.

[7]McEarchern JA, Kobie JJ, Mack V, et al.Invasion and metastasis of a mammarytumor involves TGF-βsignaling[J].Int J Cancer, 2001, 91 (1) :76-82.

[8]Wikstrom P, Damber J, Bergh A.Role of transforming growth factor-beta1in prostate cancer[J].Microsc Res Tech, 2001, 52 (4) :411-419.

[9]鲁林源, 艾开兴, 黄新余, 等.S100A4、VEGF的表达与胰腺癌预后的关系[J].肿瘤, 2008, 28 (4) :326-329.

[10]Xiong B, Gong LL, Zhang F, et al.TGF beta1expression and angio-genesis in colorectal cancer tissue[J].World J Gastroenterol, 2002, 8 (3) :496-498.

[11]安燕芳, 张魁, 徐云, 等.胃癌患者血清转化生长因子β1、癌胚抗原和糖链抗原19-9检测的临床价值[J].临床荟萃, 2007, 22 (23) :1691-1693.

[12]Ghellal A, Li C, Hayes M, et al.Prognostic significance of TGF beta1and TGF beta3in human breast carcinoma[J].Anticancer Res, 2000, 20 (6B) :4413-4418.

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