PDF下载 ( 73 KB)
The therapeutic efficacy of Mannatide Tablets in the treatment of Lamivudine-resistant chronic hepatitis B
-
摘要: 目的观察甘露聚糖肽联合阿德福韦酯治疗拉米夫定耐药的慢性乙型肝炎疗效。方法采用非随机同期对照试验,将45例拉米夫定治疗产生耐药的患者分为治疗组和对照组,治疗组24例,对照组21例。治疗组给予甘露聚糖肽10mg一日三次,同时口服阿德福韦酯10mg,每天一次,治疗12个月。对照组给予口服阿德福韦酯10mg,每天一次,治疗12个月。观察患者临床症状、ALT复常率、HBeAg转阴率、HBeAg血清转换率、HBVDNA转阴率。结果治疗3、6、12个月时,ALT复常率治疗组分别为67.8%、84.3%、90.5%,对照组分别为51.2%、63.2%、79.6%,两组比较x2值分别为9.6、12.4、8.7,P值均<0.01,差异有统计学意义。治疗组6、12个月HBVDNA阴转率、HBeAg阴转率、HBeAg血清转换率均优于对照组,两组比较,P值均<0.01,差异有统计学意义。结论甘露聚糖肽联合阿德福韦酯治疗拉米夫定耐药的慢性乙肝能有效地改善肝功能,提高阿德福韦酯抑制HBV复制。Abstract: Objective To evaluate the effect of Mannatide Tablets in combination with Adefovir Dipivoxil for the treatment Lamivudine-resistant chronic hepatitis B (CHB) patients.Methods A total of 45 CHB patients were randomly divided into 2 groups, 24 in the treatment group, and 21 in the control group.Adefovir Dipivoxil and Adefovir Dipivoxil combined with Mannatide tablets for 12 months were given for the control and the treatment groups, respectively.At the 3rd, 6th and 12th months of treatment the clinical symptoms were assessed and the levels of ALT, HBeAg and HBV DNA were measured.Results At the 3rd, 6th and 12th months of treatment, the ALT normalization rates in the treatment group (67.8%, 84.3% and 90.5%) were higher than the control group (51.2%, 63.2%, 79.6%, P<0.01) .At the 6th and l2th months, HbeAg seroconversion and HBV DNA negativity were higher in the treatment group compared to the control group (P<0.01) .Conclusion Mannatide Tablets combined with Adefovir Dipivoxil is more effective than Adefovir Dipivoxil alone in the treatment of CHB patients.
-
Key words:
- chronic hepatitis B /
- Adefovir Dipivoxil /
- Mannatide Tablets
-
[1]Baker DE.Adefovir dipivoxil:focus on its use in the treatment of chronic hepatitis B[J].Rev Gastroenterol Disord, 2005, 5 (2) :89-100. [2] 秦艳丽, 张继明, 黄玉仙, 等.阿德福韦治疗拉米夫定耐药慢性乙型肝炎患者的耐药率及对药株进化情况[J].中华肝脏杂志, 2007, 11 (5) :4-7. [3]王宇明, 陈耀凯, 张大志, 等.阿德福韦酯治疗拉米夫定耐药慢性乙型肝炎的临床研究[J].中华肝脏病杂志, 2006, 14 (11) :803-805. [4]曹天高.瞵甲酸钠联合阿德福韦酯治疗慢性乙型肝炎的临床研究[J].临床肝胆病杂志, 2008, 23 (8) :248-250. -
本文二维码
计量
- 文章访问数: 312
- HTML全文浏览量: 43
- PDF下载量: 93
- 被引次数: 0
下载:
