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The relationship between nonalcoholic fatty liver disease and insulin resistance
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摘要: 目的探讨非酒精性脂肪性肝病（NAFLD）与胰岛素抵抗（IR）的关系。方法NAFLD组52例,非NAFLD组50例,比较两组间BMI、WHR、TC、TG、CRP、HDL-C、LDL-C、ALT、Cr、FBG、FINS和HOMA-IR的差异,并进行Logistic回归分析。结果NAFLD组与非NAFLD组在BMI（26.7±2.3与22.4±2.5,P<0.01）、WHR（0.94±0.06与0.83±0.05,P<0.01）、TG（2.4±0.6与1.8±0.6,P<0.01）、ALT（37.3±8.3与28.1±7.2,P<0.05）、FBG（6.2±1.4与5.2±0.7,P<0.01）、FINS（23.6±13.6与8.6±3.5,P<0.01）、HOMA-IR（6.7±4.7与2.0±1.6,P<0.01）的差异有统计学意义,Logistic回归分析显示BMI（P<0.01）、WHR（P<0.01）、TG（P<0.01）、ALT（P<0.05）、HOMA-IR（P<0.01）是NAFLD的独立影响因素。结论B...Abstract: Objective o explore the relationship between nonalcoholic fatty liver disease (NAFLD) and insulin resistance.Methods A total of 102 liver disease patients (52 NAFLD and 50 non NAFLD) were included in the study.BMI, WHR, TC, TG, CRP, HDL-C, LDL-C, ALT, Cr, FBG, FINS and HOMA-IR were compared between the two groups were analyzed using logistic regression.Results In NAFLD group, the level of BMI (26.7±2.3 vs 22.4±2.5, P<0.01) , WHR (0.94±0.06 vs 0.83±0.05, P<0.01) , TG (2.4±0.6 vs 1.8±0.6, P<0.01) , ALT (37.3±8.3 vs 28.1±7.2, P<0.05) , FBG (6.2±1.4 vs 5.2±0.7, P<0.01) , FINS (23.6±13.6 vs 8.6±3.5, P<0.01) , HOMA-IR (6.7±4.7 vs 2.0±1.6, P<0.01) were higher than the non NAFLD group.In the logistic regression analysis BMI (P<0.01) , WHR (P<0.01) , TG (P<0.01) , ALT (P<0.05) and HOMA-IR (P<0.01) were independent factors.Conclusion BMI, WHR, TG, ALT and HOMA-IR were independent factors of NAFLD.
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Key words:
- non-alcoholic fatty liver /
- insulin resistance
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