PDF下载 ( 175 KB)
The relationship between nonalcoholic fatty liver disease and insulin resistance
-
摘要: 目的探讨非酒精性脂肪性肝病（NAFLD）与胰岛素抵抗（IR）的关系。方法NAFLD组52例,非NAFLD组50例,比较两组间BMI、WHR、TC、TG、CRP、HDL-C、LDL-C、ALT、Cr、FBG、FINS和HOMA-IR的差异,并进行Logistic回归分析。结果NAFLD组与非NAFLD组在BMI（26.7±2.3与22.4±2.5,P<0.01）、WHR（0.94±0.06与0.83±0.05,P<0.01）、TG（2.4±0.6与1.8±0.6,P<0.01）、ALT（37.3±8.3与28.1±7.2,P<0.05）、FBG（6.2±1.4与5.2±0.7,P<0.01）、FINS（23.6±13.6与8.6±3.5,P<0.01）、HOMA-IR（6.7±4.7与2.0±1.6,P<0.01）的差异有统计学意义,Logistic回归分析显示BMI（P<0.01）、WHR（P<0.01）、TG（P<0.01）、ALT（P<0.05）、HOMA-IR（P<0.01）是NAFLD的独立影响因素。结论B...Abstract: Objective o explore the relationship between nonalcoholic fatty liver disease (NAFLD) and insulin resistance.Methods A total of 102 liver disease patients (52 NAFLD and 50 non NAFLD) were included in the study.BMI, WHR, TC, TG, CRP, HDL-C, LDL-C, ALT, Cr, FBG, FINS and HOMA-IR were compared between the two groups were analyzed using logistic regression.Results In NAFLD group, the level of BMI (26.7±2.3 vs 22.4±2.5, P<0.01) , WHR (0.94±0.06 vs 0.83±0.05, P<0.01) , TG (2.4±0.6 vs 1.8±0.6, P<0.01) , ALT (37.3±8.3 vs 28.1±7.2, P<0.05) , FBG (6.2±1.4 vs 5.2±0.7, P<0.01) , FINS (23.6±13.6 vs 8.6±3.5, P<0.01) , HOMA-IR (6.7±4.7 vs 2.0±1.6, P<0.01) were higher than the non NAFLD group.In the logistic regression analysis BMI (P<0.01) , WHR (P<0.01) , TG (P<0.01) , ALT (P<0.05) and HOMA-IR (P<0.01) were independent factors.Conclusion BMI, WHR, TG, ALT and HOMA-IR were independent factors of NAFLD.
-
Key words:
- non-alcoholic fatty liver /
- insulin resistance
-
[1]Angulo P.Obesity and nonalcoholic fatty liver disease[J].Nutr Rev, 2007, 65 (S1) :S57-63. [2]Grant LM, Lisker MM.Nonalcoholic fatty liver disease[J].Ann Hepatol, 2004, 3 (3) :93-99. [3] 中华医学会肝脏病学分会脂肪肝和酒精性肝病学组.非酒精性脂肪肝病诊疗指南[J].中华肝脏杂志, 2006, 14 (2) :161-163. [4]Bedogni G, Bellentani S.Fatty liver, howfrequent is it and why[J].Ann Hepatol, 2004, 3 (2) :63-65. [5]Fan JG, Zhu J, Li XJ, et al.Prevalence of and risk factors for fatty liver in a general population of Shanghai, China[J].J Hepatol, 2005, 43 (3) :508-514. [6]Gupte P, Amarapurkar D, Agal S, et al.Non-alcoholic steatohepa-titis in type2diabetes mellitus[J].Gastroenterol Hepatol, 2004, 19 (8) :854-858. [7]Methta K, van Thiel DH, Shah N, et al.Nonalcoholic fatty liver dis-ease:pathogenesis and the role of antioxidants[J].Nutr Rev, 2002, 60 (9) :289-293. [8]何淑梅, 孔俭, 牛俊奇.非酒精性脂肪性肝病研究现状及进展[J].中国老年学杂志, 2008, 28 (4) :725-727. [9]展玉涛.非酒精性脂肪肝与心血管疾病[J].中华内科杂志, 2007, 46 (10) :868-869. [10]Clark JM, Brancati FL, Diehl AM.The prevalence and etiology of elevated aminotransferase levels in the United States[J].Am J Gas-troenterol, 2003, 98 (5) :960-967. [11]Schindhelm RK, Diamant M, Jacqueline M, et al.Alanine amin-otransferase as a marker of non-alcoholic fatty liver disease in rela-tion to type2diabetes mellitus and cardiovascular disease[J].Dia-betes Metab Res Rev, 2006, 22 (6) :437-443. [12]Choudhury J, Sanyal AJ.Insulin resistance and the pathogenesis of nonalcoholic fatty liver disease[J].Clin Liver Dis, 2004, 8 (3) :575-594. [13]Newschwander-Tetri BA.Nonalcoholic steatohepatitis and the metabolic syndrome[J].Am J Med Sci, 2005, 330 (6) :326-335. [14]Bansilal S, Farkouh ME, Fuster V.Role of insulin resistance and hyperglycemia in the development of atherosclerosis[J].Am J Car-diol, 2007, 99 (4A) :6B-14B. [15]Bradbury MW.Lipid metabolism and liver inflammation.Hepatic fatty acid uptake:possible role in steatosis[J].Am J Physiol Gas-trointest Liver Physiol, 2006, 290 (2) :G194-G198. -
本文二维码
计量
- 文章访问数: 3341
- HTML全文浏览量: 28
- PDF下载量: 1261
- 被引次数: 0
下载:
