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血清脂联素的表达及肝功能、肝脾CT值等联合检测对非酒精性脂肪肝诊断的临床意义

许腊梅 孙丹莉 张予蜀 张振玉 袁捷 杜同信

引用本文:
Citation:

血清脂联素的表达及肝功能、肝脾CT值等联合检测对非酒精性脂肪肝诊断的临床意义

基金项目: 

南京市卫生局资助项目(YKK05076); 

详细信息
  • 中图分类号: R575.5

The clinical significance of adiponectin expression and its diagnostic value combined with liver function tests and liver/spleen CT value in Non-alcoholic fatty liver disease

Research funding: 

 

  • 摘要: 目的探讨血清脂联素的表达及肝功能、肝脾CT值等联合检测对非酒精性脂肪性肝病(NAFLD)诊断的临床意义。方法选取NAFLD患者71例,分为轻、中、重三组;对照组41例。检测ALT、AST、GGT、TG、TC、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)及脂联素,分析脂联素与各临床指标的相关性,NAFLD组与对照组、NAFLD不同组间上述指标的变化。结果(1)与对照组比较,NAFLD组的脂联素水平、肝脏CT值、CT肝脾比值、HDL-C明显降低(P<0.01),BMI、ALT、AST、TG、TC、GGT、LDL-C明显增高(P<0.01);(2)脂联素与BMI、ALT、AST、GGT、LDL-C呈负相关,与肝脏CT值、HDL-C呈正相关;(3)ALT在轻度与中度、轻度与重度组间表达有统计学意义(P<0.05),而中度与重度组间差异表达无统计学意义(P>0.05)。结论联合检测脂联素、ALT对于NAFLD的诊断和鉴别诊断有临床意义。

     

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  • 出版日期:  2010-02-20
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