脂肪肝与非脂肪肝患者血常规的差异分析

秦永军; 孙杰生; 王炳元; 刘鹏亮; 孙福荣; 刘翠香; 谢大伟

脂肪肝与非脂肪肝患者血常规的差异分析

中国医科大学附属第一医院消化内科

基金项目:

辽宁省教育厅科技攻关项目(编号:2007225011-1)；

详细信息

中图分类号: R575.5
计量
- 文章访问数: 4056
- HTML全文浏览量: 31
- PDF下载量: 1049
- 被引次数: 0
出版历程
- 出版日期: 2010-02-20

The differences of the blood routine indexes in patients with fatty liver and non-fatty liver

Research funding:

摘要

摘要: 目的探讨成人脂肪肝患者与非脂肪肝患者血常规的差异。方法选用沈阳地区2008年3月～2008年12月参加体检的18岁以上人群为研究对象,对肝脏彩色多普勒检查诊断的脂肪肝与非脂肪肝患者,采用问卷咨询、体格检查和生化检查外,重点探讨脂肪肝与血常规之间的关系,数据用SPSS16.0软件分析。结果入选人群共8842名,B超共检出脂肪肝3306例,占37.39%,其中酒精性、非酒精性脂肪肝分别占15%（1326名）和22.39%（1980名）,与非脂肪肝组（NAFL）相比,脂肪肝组（AFL）WBC（白细胞计数）、EO%（嗜酸性细胞比率）、RBC（红细胞计数）、HGB（血红蛋白浓度）、HCT（红细胞比积测定）、MCH（平均红细胞Hb含量）、MCHC（平均红细胞Hb浓度）、RDW（红细胞分布宽度）、PDW（血小板分布宽度）显著增加（P<0.01）;LYM%（淋巴细胞比率）、MONO%（单核细胞比率）、MCV（平均细胞容积）、P-LCR（大型血小板比率）、MPV（平均血小板体积）等明显增加（P<0.05）;PLT（血小板计数）明显减少（P<0.05）;与非酒精性脂肪肝组（NAFL）比,...
- 脂肪肝 /
- 酒精性脂肪肝 /
- 非酒精性脂肪肝 /
- 血常规
Abstract: Objective To investigate the differences of the blood routine indexes in patients with fatty liver and non-fatty liver.Methods Objects include adults who participated in physical examination in Shenyang between March, 2008 and Dec, 2008.For those with fatty liver and non-fatty liver found by ultrasonography, we mainly focus on the relationship between the fatty liver and blood routine indexes besides the use of the consultation questionnaire, physical examination and biochemistry, .The data was analyzed with spss16.0.Results Of the 8842 subjects, the incidence of fatty liver is 37.39% (3306) with alcoholic fatty liver 15% (1326) and non-alcoholic fatty liver22.39% (1980) respectively.Compared with the non-fatty liver group, WBC (white blood cell count) , EO% (eosinophil ratio) , RBC (red blood cell count) , HGB (hemoglobin concentration) , HCT (hematocrit determination) , MCH (mean corpuscular Hb concentration) , MCHC (mean corpuscular Hb concentration) , RDW (red blood cell distribution width ) , PDW (platelet distribution width) were markedly increased (P<0.01) in the fatty liver group;LYM% (lymphocyte ratio) , MONO% (the ratio of mononuclear cells) , MCV (mean corpuscular volume) , P-LCR (the ratio of large platelets) , MPV (mean platelet volume) were significantly increased (P<0.05) ;while PLT (platelet count) was significantly reduced (P<0.05) ;Compared with the non-alcoholic fatty liver group, RBC, HGB, HCT, MCV, MCHC were significantly increased (P<0.01) ;LYM% was significantly reduced (P<0.05) ;MCH, MONO% was significantly increased (P<0.05) in the alcoholic fatty liver group.Conclusion Compared with the non-fatty liver group, the total number and differential count (except the percentage of neutrophils) of leukocytes in patients with fatty liver were significantly higher with a similar trend for erythroid cells (except MCHC) , while the platelet count was significantly reduced.Moreover, a significant increase in erythroid cells (especially in MCV) was observed in alcoholic fatty liver group compared to the non-alcoholic fatty liver group, while no significant differences were obtained in the leukon and platelets system except a decrease in LYM%.These fully explained the significant importance of blood routine test as well as differential count for the etiological and clinical diagnosis of fatty liver.
- fatty liver /
- alcoholic fatty liver /
- non-alcoholic fatty liver /
- blood routine test

HTML全文

参考文献(20)

[1]Day CP.Non-alcoholic fatty liver disease:current concepts and management strategies[J].ClinMed, 2006, 6 (1) :19-25.

[2]Targher G, Arcaro G.Non-alcoholic fatty liver disease and in-creased risk of cardiovascular disease[J].Atherosclerosis, 2007, 191 (2) :235-240.

[3] 中华医学会肝病学分会脂肪肝和酒精性肝病学组.酒精性肝病诊疗指南[J].中华肝脏病杂志, 2006, 14 (3) :164-166.

[4]中华医学会肝脏病学分会脂肪肝和酒精性肝病学组.非酒精性脂肪性肝病诊疗指南[J].中华肝脏病杂志, 2006, 14 (3) :161-163.

[5]范建高, 李锋, 蔡晓波, 等.1995至2002年上海宝钢职工队列人群脂肪肝患病率变化[J].肝脏, 2006, (11) 3:154-157.

[6]范建高.非酒精性脂肪肝的临床流行病研究[J].中华消化杂志, 2002, 22 (2) :106-107.

[7]马金霞, 张建富, 李嘉陵, 等.平均红细胞体积和红细胞体积分布宽度临床意义的分析[J].南京医科大学学报, 2001;21 (2) :13.

[8]张桂芹, 关盼香.脂肪肝患者血脂与PLT和红细胞粒度分布的相关性分析[J].中国现代药物应用杂志, 2009, 3 (10) :62.

[9]谭力学, 李孝生, 刘增权.非酒精性脂肪肝患者红细胞容积分布密度变化的观察及其临床意义[J].陕西医学杂志, 2003, 32 (12) :1072-1073.

[10] 董蕴.红细胞变形能力下降的机理研究[J].中风与神经疾病杂志, 1993, 10 (3) :145.

[11]胡学琴.红细胞的检测在非酒精性脂肪肝早期诊断中的重要价值[J].实用医技杂志, 2004, 11 (17) :1716.

[12]Takashimizu S, Shiraishi K, Watanabe N, et al.Scanning electron microscopic studies on morphological abnormalities of erythrocytes in alcoholic liver diseases[J].Alcohol Clin Exp Res, 2000, 24 (Suppl4) :S81-S86.

[13]王泰龄, 江正辉.酒精性肝病[M].北京:中国医药出版社, 2001:57—60.

[14]Kazemi-Shirazi L, Veloso MP, Frommlet F, et al.Differentiation of nonalcoholic from alcoholic steatohepatitis:are routine laboratory markers useful[J].Wien Klin Wochenschr, 2008, 120 (1-2) :25-30.

[15]Maruyama S, Hirayama C, Yamamoto S, et al.Red blood cell sta-tus in alcoholic and non-alcoholic liver disease[J].J Lab Clin Med, 2001, 138 (5) :332-337.

[16]Shella S.Diseases of The Liver And Biliary Syste[M].Eleventh E-dition.London:Blackwell Publishing, 2002:90.

[17]kaneda H, Hashimoto E, Yatsuji S, et al.Hyaluronic acid levels can predict severe fibrosis and platelet counts can predict cirrhosis in patients with nonalcoholic fatty liver disease[J].Gastroenterol Hepa-tol, 2006, 21 (9) :1459-1465.

[18]陈彤君.脂肪肝患者平均血小板体积和血清脂质变化的临床研究[J].北京医学, 2005, (27) 8:484.

[19]Craig W S.Increased platelet volume sign of in paired thrombopoi-esis in diabetes mellitus[J].K1in Wochenschr, 1995, 37:157-158.

[20]Park KS, Lee YS, Park HW, et al.Factors associated or related to with pathological severity of nonalcoholic fatty liver disease[J].Ko-rean J Intern Med, 2004, 19 (1) :19-26.

施引文献

资源附件(0)

访问统计