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趋化因子XCL1的免疫调节作用与相关疾病的研究

沈兰超 左维泽

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趋化因子XCL1的免疫调节作用与相关疾病的研究

详细信息
  • 中图分类号: R392

Studies on the immunomodulatory effect of chemokine XCL1 and related diseases


  • 摘要:

    <正>趋化因子(chemokine)是一类对不同靶细胞具有趋化效应的的细胞因子家族,已发现50多个成员。该家族成员依据其分子氨基端半胱氨酸的数目及其间隔,可分为CC、CXC、C、CX3C四个亚家族。

     

  • [1]吴玉章.基础免疫学[M].北京:科学出版社, 2003∶871-872.
    [2]Yoshida T, Imai T, Kakizaki M, et al.Identification of single C motif-1/lymphotactin receptor XCR1[J].J Biol Chem, 1998, 273 (26) ∶16551-16554.
    [3]Kurt RA, Bauck M, Harma S, et al.Role of C chemokine lymphotac-tin in mediating recruitment of antigen-specific CD62L (lo) cells in vitro and in vivo[J].Cell Immunol, 2001, 209 (2) ∶83-88.
    [4]Chantal C, Elisabeth D, Luc X, et al.The C-class chemokine lymphotactin costimulates the apoptosis of human CD4+T cells[J].Blood, 2001, 97 (8) ∶2205-2212.
    [5]Sheng XL, Zhang H.In-vitro activation of cytotoxic T lymphocytes by fusion of mouse hepatocellular carcinoma cells and lymphotactin gene-modified dendritic cells[J].World journal of gastroenterology, 2007, 13 (44) ∶5944-5950.
    [6]岳艳, 徐薇, 蒋正刚, 等.C家族趋化因子XCL1增强CVB3基因疫苗的抗病毒免疫应答及保护作用[J].现代免疫学, 2008, 28 (2) ∶91-95.
    [7]温文沛, 谭耀驹, 许婉华, 等.初治肺结核患者外周血CD4+/CD8+T细胞、IgG/IgM抗体与感染程度的相关性[J].广东医学, 2007, 28 (8) ∶1268-1270.
    [8]Bo-Chin C, Christine MF, Valerie RS, et al.Cytokine-Chemo-kine Networks in Experimental Mycobacterial and Schistosomal Pul-monary Granuloma Formation[J].American journal of respiratory cell and molecular biology.2003, 29 (1) ∶106-116.
    [9]Diane0, David MH, Joaquin SC, et al.XCL1 (lymphotactin) che-mokine produced by activated CD8T cells during the chronic stage of infection with Mycobacterium tuberculosis negatively affects produc-tion of IFN-γby CD4T cells and participates in granuloma stability[J].Journal of leukocyte biology, 2007, 82 (5) ∶1221-1229.
    [10]Kuciak M, Gabus C, Ivanyi-Nagy R, et al.The HIV-1transcrip-tional activator Tat has potent nucleic acid chaperoning activities in vitro[J].Nucleic Acids Res, 2008, 36 (10) ∶3389-3400.
    [11]Byung OK, Ying L, Betty Y, et al.Induction of C Chemokine XCL1 (Lymphotactin/Single C Motif-1α/Activation-Induced, T Cell-Derived and Chemokine-Related Cytokine) Expression by HIV-1Tat[J].Journal of immunology, 2004, 172 (3) ∶1888-1895.
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  • 出版日期:  2010-01-20
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