Objective To analyze the clinical features of patients diagnosed as hepatic amyloid degeneration to improve the current understanding of the disease and decrease misdiagnosis.Methods A total of 4 patients were diagnosed with hepatic amyloid degeneration based on the pathology results gained from the aspiration samples of liver or kidney and specific dyeing (Congo red dye) .Liver function tests, blood fat, routine urine tests, abdominal ultrasound and CT or MRI of the patients were performed.Results All patients had hepatomegaly, significant elevation of AKP and r-GT, hypoproteinemia and hyperlipidemia.Hepatic ultrasound and CT showed an enlarged liver and with low density, and the hepatic echo was fine and closely similar with the features of fatty liver.Pathologic results of liver or kidney aspirate showed sedimentation of pink amyloid matters.Congo red dye test was positive and pathological consequence was hepatic and renal amyloidosis.Conclusion Liver or kidney aspirate examination and specific dyeing (Congo red dye) is necessary in patients suspected with hepatic amyloid degeneration.