Abstract: Objective To observe the therapeutic effect and security of PHGF, wujibaifeng pill combined with salviate milttiorrhize on the cirrhotic hypoproteinemia.Methods 68 patients with cirrhotic hypoproteinemia were randomly divided into treatment group (n=36) and control group (n=32) .The control group were treated with salviate milttiorrhize by intravenous drip on the basis of routine treatment, while the treatment group were given PHGF by intravenous drip and wujibaifeng pill by orally taken on the basis of control group, each for a treatment course of 60 days.The clinical data including main symptoms, hepatic function and blood coagulation tests were monitored before therapy and on the 30th and 60th days of therapy, and the adverse effects were also monitored after therapy.Results ymptoms of the treatment group improved better than those of the control group (P < 0.05, P < 0.01) .Total effective rates of the treatment group (83.3% ) was higher than that of the control group (53.1% ) (P < 0.01) .The level of aspartate transaminase (AST) , alanine transaminase (ALT) , total bilirubin (TBil) were lower and the level of plasma total protein (TP) , albumin (ALB) , prothrombin active (PTA) were higher in the treatment group than the control group (P <0.05, P <0.01) .No remarkable adverse effects in treatment were observed.Conclusion PHGF, wujibaifeng pill combined with salviate milttiorrhize is effective and safe in the treatment of cirrhotic hypoproteinemia.