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Association between HBV infection and prevalence of chronic cholecystitis
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摘要: 目的研究HBVDNA、HBV基因型与慢性胆囊炎发病之间的关系。方法对566例乙型肝炎患者采用荧光定量PCR方法检测血清HBVDNA、HBV基因型及肝胆B超检查等。(检测HBVDNA及基因型应用的均为实时定量PCR方法,只是试剂盒不同)结果不同HBV基因型患者的慢性胆囊炎患病率存在统计学差异,HBV基因C型患者慢性胆囊炎的患病率明显高于非HBV基因C型(72.5%vs54.4%,x2=9.369,P<0.01);血清HBVDNA定量水平与慢性胆囊炎的患病无统计学意义(x2=1.171,P>0.05)。结论HBV基因C型可能与慢性乙型肝炎患者中慢性胆囊炎的患病相关。Abstract: Objective To study the association of HBVDNA, HBV genotype and the prevalence of chronic cholecystitis.Methods Serum HBV DNA level and HBV genotype were detected using real-time fluorescence PCR assay in 566 chronic hepatitis B patients.B-ultrasonography was used to examine the liver and gallbladder of all the patients.Results The prevalence of chronic cholecystitis was significantly higher in HBV genotype C patients compared with patients with genotype non-C (72.5% vs 54.4% , x2=9.369, P < 0.01) .However, there was no statistically difference between HBVDNA level and the prevalence of chronic cholecystitis (x2=1.171, P > 0.05) .Conclusion HBV genotype C might be associated with the prevalenc of chronic cholecystitis in chronic hepatitis B patients.
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Key words:
- Hepatitis B virus /
- Chronic cholecystitis /
- genotype
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