阿德福韦酯对慢性乙型肝炎患者Th1/Th2型细胞因子的影响

罗芳琼; 潘煜; 刘晶晶; 张鹏; 牛俊奇; 姜艳芳

阿德福韦酯对慢性乙型肝炎患者Th1/Th2型细胞因子的影响

1. 吉林大学第一医院肝胆胰内科
2. 聊城市人民医院感染病科

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中图分类号: R512.62
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出版历程
- 出版日期: 2010-01-20

The Impact of Adefovior dipivoxil on Th1/Th2 cytokines in chronic hepatitis B Patients

摘要

摘要: 目的分析细胞因子IFN-γ、TNF-α、IL-10、IL-6、IL-4、IL-2在慢性乙型肝炎患者治疗后血清中的浓度改变及其临床意义。方法应用微阵列流式细胞术（CBA）体外检测慢性乙型肝炎患者治疗前、治疗12周、24周、48周的血清细胞因子IFN-γ、TNF-α、IL-10、IL-6、IL-4、IL-2的浓度。结果慢性乙型肝炎患者阿德福韦酯治疗后外周血清的TH1/TH2细胞因子浓度度,比较治疗前,均是显著升高的（P<0.05）,除IL-6外,各细胞因子在治疗过程中均未有显著变化（P>0.05）;治疗12周时的血清IL-6的浓度与HBVDNA成负相关,治疗24周,IL-6、IL-10、TNF-α与HBVDNA成负相关（P<0.05）。结论阿德福韦酯除直接抑制病毒作用外,还可能通过免疫调节作用抑制病毒复制。
- 慢性乙型肝炎 /
- 细胞因子 /
- 阿德福韦酯 /
- 微阵列流式细胞术
Abstract: Objective To analyze the changes in Th1/Th2 cytokines level in chronic hepatitis B patients during Adefovir dipivoxil therapy.Methods The serum levels of TNF-α, IFN-γ, IL-10, IL-6, IL-4 and IL-2 were measured in chronic hepatitis B (CHB) patients using Cytotoxic Bead Array (CBA) technique.Results After 12, 24, and 48 weeks of treatment, the serum levels of TNF-α, IFN-γ, IL-10, IL-4 and IL-2 in CHB patients were significantly increased compared to the baseline (P < 0.05) .At the 12th week of treatment, IL-6 was negatively correlated with HBV DNA and after 24 weeks of treatment, IL-6, IL-10 and TNF-α were negatively correlated with HBV DNA (P < 0.05) .Conclusion Adefovir dipivoxil may inhibit HBV DNA replication through the immune pathway.
- Chronic Hepatitis B /
- cytokine /
- Adefovir Dipivoxil /
- Cytotoxic Bead Array

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参考文献(9)

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