Abstract: Objective To detect the changes in the serum level and investigate the relationship and clinical significance of retinol-binding protein (RBP) , pre-albumin (PA) and albumin (ALB) in patients with hepatitis B cirrhosis.Methods The levels of serum RBP and PA were measured by immunotransmission turbidity and serum ALB was detected by bromocreosol green method in 89 patients with hepatitis B cirrhosis and 35 healthy controls.Results The levels of serum RBP, PA and ALB in patients with hepatitis B cirrhosis were significantly lower than the control group (p<0.01) .Serum RBP was positively correlated with PA (r=0.743, p<0.01) .Furthermore, serum RBP and PA were also positively correlated with ALB (r1=0.602, r2=0.529, p<0.01) .The levels of serum RBP, PA and ALB were correlated with the degree of liver damage.Conclusion Serum RBP, PA and ALB can be used as an index to reflect the degree of liver damage.Serum RBP is more sensitive to reflect changes of liver function.Combined measurement of serum RBP, PA and ALB can be useful markers to evaluate the liver function in patients with hepatitis B cirrhosis.