PDF下载 ( 96 KB)
Therapeutic Efficacy of telbivudine with phentolamine on patients with chronic severe hepatits B
-
摘要: 目的研究替比夫定联合酚妥拉明治疗慢性乙型重型肝炎的疗效。方法将60例患者随机分为两组,治疗组30例,采用替比夫定联合酚妥拉明治疗;对照组30例,静点茵栀黄注射液。两组均予以支持对症治疗。观察两组TBil(血清总胆红素),PTA(凝血酶原活动度),HBVDNA变化情况。结果治疗4周,治疗组在TBil降低的程度上与对照组比较差异有统计学意义(P<0.05)。治疗6周,治疗组在升高PTA值与对照组比较有统计学意义(P<0.05)。且治疗组临床疗效明显优于对照组,治疗6周临床总有效率达70%。治疗组在HBVDNA定量下降≥1log10copies/mL与对照组比较有统计学意义(P<0.05)。结论替比夫定联合酚妥拉明治疗对慢性重型肝炎TBil降低、PTA值升高、HBVDNA定量下降有较好疗效。Abstract: Objective To study the efficacy of telbivudine combined with phentolamine on chronic severe hepatits B patients.Methods 60 patients were randomly divided into two groups.The treatment group (n=30) were treated with telbivudine and phentolamine, while the control group (n=30) were treated with Yinzhihuang.Additionally, both groups were given supportive symptomatic therapy.Serum total bilirubin (TBIL) , PTA and HBV DNA were analyzed.Results TBIL in treatment group was decreased significantly after 4 weeks of therapy (p<0.05) .PTA and clinical conditions of the patients in the treatment group were significantly improved after 6 weeks of treatment (p<0.05) .The total treatment efficacy was found to be 70%.The level of HBV DNA in treatment group was significantly decreased compared with that of the control group (p<0.05) .Conclusion Telbivudine combined with phentolamine has a better effect on chronic severe hepatitis B patients.
-
Key words:
- telbivudine /
- phentolamine /
- severe hepatitis /
- therapy
-
[1]中华医学会.病毒性肝炎防治方案[J].中华肝脏病杂志, 2000, 8 (6) ∶326. [2]徐君, 张园海.拉米夫定治疗慢性乙型重型肝炎近期疗效观察[J].实用肝脏病杂志, 2004, 7 (4) ∶214-216. [3]Villeneu JP, Condreay LD, Willems B, et al.Lamivudine treatment for decompensated cirrhosis resul-ting from chronic hepatitis B[J].Hepatology, 2000, 31 (1) ∶207-210. [4]Yoshiba M.Recent advances in the treatment of fulminant hepatitisB[J].Nippon Rinsho, 2004, 62 (Suppl8) ∶280-283. [5]梁月兰, 黄春新.治疗慢性乙肝新药——素比伏 (替比夫定片) [J].中南药学, 2007, 5 (3) ∶285-287. [6]高寿征.病毒性肝炎防治研究[M].北京:北京出版社, 1993∶198. [7]何桂香.小剂量肝素、立其丁联合治疗慢性淤胆型肝炎疗效观察[J].临床肝胆病杂志, 2003, 19 (1) ∶37-38. [8]任安吉, 邱磷安, 林赛金, 等.酚妥拉明治疗重型肝炎35例[J].中西医结合肝病杂志, 1999, 9 (2) ∶65-66. -
本文二维码
计量
- 文章访问数: 2137
- HTML全文浏览量: 24
- PDF下载量: 727
- 被引次数: 0
下载:
