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摘要: 目的观察肿瘤坏死因子相关凋亡诱导配体(TRAIL)在HBV感染所致免疫损伤中的作用。方法选择慢性乙肝患者(CHB)20例,乙肝病毒携带者(ASC)20例,正常健康者10例,ELISA检测其血清sTRAIL水平,同时检测血清IFN-γ和ALT水平。结果ASC组和CHB组sTRAIL水平明显高于正常健康组(P(0.01),且CHB组高于ASC组(P(0.01);CHB组IFN-γ水平明显高于正常组和ASC组(P(0.05),而正常组和ASC组之间差异无统计学意义(P(0.05)。在CHB中sTRAIL水平与ALT的值呈正相关(P(0.01)。结论TRAIL在IFN-γ的协同作用下,参与了HBV感染所致的免疫损伤,在HBV感染所致免疫损伤中起重要作用。Abstract: Objective To explore the effect of TRAIL on the immunolesion in patientswith chronic hepatitis B.Methods The serum level of sTRAIL of 20 patients with chronic hepatitis B (CHB) and 20 patients with asymptomatic HBV carriage (ASC) and 10 healthy people was determined by specific-ELISA, while the serum level of IFN-γ and ALT was determined.Results The level of TRAIL of CHB group and ASC group were higher than that of normal group (P﹤0.01) , while the level of TRAIL of CHB group were higher than that of ASC (P﹤0.01) .The level of IFN-γ of CHB group were higher than that of healthy people and ASC (P﹤0.05) .In the CHB group, the expression level of sTRAIL was positively related to the ALT value (P﹤0.01) .Conclusion With the cooperation of IFN-γ, TRAIL probably plays a key role on the immunolesion in patients with chronic hepatitis B.
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Key words:
- chronic hepatitis B /
- immunolesion /
- TRAIL /
- IFN-γ
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