原发性肝癌患者血清β2-微球蛋白含量变化的临床意义

刘强; 潘光栋; 褚光平; 杨建青

原发性肝癌患者血清β2-微球蛋白含量变化的临床意义

广西医科大学第五附属医院柳州市人民医院

详细信息

中图分类号: R735.7
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出版历程
- 出版日期: 2009-04-20

摘要

摘要: 目的探讨原发性肝癌患者血清β2-微球蛋白（β2-microglobulin,β2-MG）含量变化及临床应用价值。方法用免疫放射分析法（RIA）检测64例原发性肝癌患者、55例肝硬化、以及48例正常健康人血清β2-MG含量;动态检测原发性肝癌手术前后β2-MG含量变化。结果原发性肝癌组血清中β2-MG含量明显高于健康对照组（P<0.05）和肝硬化组（P<0.05）;原发性肝癌术前血清β2-MG含量增高者,术后含量明显降低,有转移复发时,β2-MG含量再度升高。结论检测血清β2-MG含量变化在原发性肝癌辅助诊断以及疗效、复发判断方面具有重要临床意义。
- 肝癌 /
- β2-微球蛋白
Abstract: Objective To study the clinical evaluation of serum β2-MG in hepatocarcinoma.Methods By using RIA, the levels of serum β2-MG of the health adults, patients with hepatocarcinoma, liver cirrhosis (LC) , operative patients before and after operation.Results Serum β2-MG levels of hepatocarcinoma are higher than that of the health adults, patients with LC, In health adults and patients with LC there is no significantly difference of β2-MG.The high Serum β2-MG levels in preoperative patients were reduced dramatically after operation (P<0.01) , however, the reduced Serum β2-MG levels raised again when matastasis or recurrence occurred.Serum β2-MG is a singly tumor marker.Conclusion The examination of serum β2-MG is helpful to the differential diagnose in hepatocarcinoma and LC;and has important significance in judgement of therapeutic effects and relapse for hepatocarcinoma
- hepatocarcinoma /
- β2-microglobulin

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参考文献(6)

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