Abstract: Objective To evaluate the clinical efficacy of Levocarnitine combined with Polyene Phosphatidylcholine in treatment of nonalcoholic steatohepatitis.Methods A total of 82 patients with nonalcoholic steatohepatitis were selected and divided randomly into two groups..In experiment group, the patients received Levocarnitine combined with polyene Phosphatidylcholine (n=41) for 12 weeks.While in control group the patients received Polyene Phosphatidylcholine oniy (n=41) for 12 weeks.The levels of serum transaminase, blood grease and liver/spleen CT index were measured before and after treatment respectively.Results The levels of serum transaminase and blood grease in experiment group were decreased obviously after treatment.Meanwhile liver/spleen CT index were increased obviously after treatment.There were a significant differece between the two groups (P<0.05) .Conclusion Treatment with Levocarnitine combined with polyene Phosphatidylcholine was an effective remedy for treating nonalcoholic steatohepatitis.It was worth of clinic application.