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摘要: 目的观察硫普罗宁联合多稀磷脂酰胆碱治疗酒精性肝病疗效。方法165例酒精性肝病患者随机分为两组。治疗组83例用硫普罗宁联合多稀磷脂酰胆碱。对照组82例采用基础护肝疗法。观察两组治疗前后肝功能、肝纤维化指标、腹部超声及肝组织病理等方面的改变。结果治疗组肝功能血清纤维化指标和腹部超声均有明显改善(P<0.01或P<0.05)。治疗组有效率96.5%(80/83),对照组有效率71.9%(59/82),两组比较有显著性差异(P<0.01),肝脏组织病理检查显示治疗组肝细胞脂肪变性、炎症、肝纤维化均有明显改善(P<0.05),两组比较脂肪变性、纤维化积分改善方面更优(P<0.05)。结论硫普罗宁联合多稀磷脂酰胆碱治疗酒精性肝病具有理想的治疗结果,值得临床推广应用。Abstract: Objective To observe the effect of Tiopronin combined with Polyene Phosphatidylcholine on alcoholic liver disease.Methods 165cases with alcoholic liver disease were randomly divided into two groups.In the treatment group, there were 83 cases who were treated with Tiopronin combined with Polyene Phosphatidylcholine.The control group was treated with basic liver-aid.Results In the treatment group, indexes that reflect liver fibrosis had significantly improved (P<0.05 or P<0.01) .Effective rate in treatment was 96.5% (80/83) , while in control group 71.9% (59/82) (P<0.01) .Liver biopsy showed that the rates of fatty degeneration of liver cells, inflammation and liver fibrosis in treatment group were significantly higher than those in control group (P<0.05) .Conclusion Combination of Tiopronin and Polyene Phospha-tidylcholine has an ideal outcome.And it is worthy of clinical application.
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Key words:
- Tiopronin /
- Polyene Phosphatidylcholine /
- liver disease /
- alcohol
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