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丙型肝炎病毒NS5A蛋白功能的研究进展

周友乾 尹凤鸣 冯经华

引用本文:
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丙型肝炎病毒NS5A蛋白功能的研究进展

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  • 中图分类号: R512.63;R373.21

  • [1]Lohmann V, Korner F, Koch JO, et al.Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line[J].Science, 1999, 285∶110-113.
    [1]Lohmann V, Korner F, Koch JO, et al.Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line[J].Science, 1999, 285∶110-113.
    [2]Elazar M, Cheong KH, Liu P, et al.Amphipathic helix-dependent localization of NS5A mediates hepatitis C virus RNA replication[J].J Virol, 2003, 77∶6055-6061.
    [2]Elazar M, Cheong KH, Liu P, et al.Amphipathic helix-dependent localization of NS5A mediates hepatitis C virus RNA replication[J].J Virol, 2003, 77∶6055-6061.
    [3]Shirota Y, Luo H, Qin WP, et al.Hepatitis C virus (HCV) NS5A binds RNA-dependent RNA polymerase (RdRP) NS5B and modu-lates RNA-dependent RNA polymerase activity[J].J Biol Chem, 2002, 277∶11149-11155.
    [3]Shirota Y, Luo H, Qin WP, et al.Hepatitis C virus (HCV) NS5A binds RNA-dependent RNA polymerase (RdRP) NS5B and modu-lates RNA-dependent RNA polymerase activity[J].J Biol Chem, 2002, 277∶11149-11155.
    [4]Qin W, Yamashita T, Shirota Y, et al.Mutational analysis of the structure and functions of hepatitis C virus RNA-dependent RNA polymerase[J].Hepatolog, 2001, 33∶728-737.
    [4]Qin W, Yamashita T, Shirota Y, et al.Mutational analysis of the structure and functions of hepatitis C virus RNA-dependent RNA polymerase[J].Hepatolog, 2001, 33∶728-737.
    [5]Shimakami T, Hijikata M, Luo H, et al.Effect of interaction be-tween hepatitis C virus NS5A and NS5B on hepatitis C virus RNA replication with the hepatitis C virus replicon[J].J Virol, 2004, 78∶2738-2748.
    [5]Shimakami T, Hijikata M, Luo H, et al.Effect of interaction be-tween hepatitis C virus NS5A and NS5B on hepatitis C virus RNA replication with the hepatitis C virus replicon[J].J Virol, 2004, 78∶2738-2748.
    [6]Iusida MI, Nagano Fujii M, Nidom CA, et al.Correlation between mutations in the interferon sensitivity-determining region of NS5A protein and viral load of hepatitis C virus subtypes1b, 1c, and2a[J].J Clin Microbiol, 2001, 39 (11) ∶3858-3864.
    [6]Iusida MI, Nagano Fujii M, Nidom CA, et al.Correlation between mutations in the interferon sensitivity-determining region of NS5A protein and viral load of hepatitis C virus subtypes1b, 1c, and2a[J].J Clin Microbiol, 2001, 39 (11) ∶3858-3864.
    [7]He Y, Yan W, Coito C, et al.The regulation of hepatitis C virus (HCV) internal ribosome-entry site-mediated translation by HCV replicons and nonstructural proteins[J].J Gen Virol, 2003, 84 (3) ∶535-543.
    [7]He Y, Yan W, Coito C, et al.The regulation of hepatitis C virus (HCV) internal ribosome-entry site-mediated translation by HCV replicons and nonstructural proteins[J].J Gen Virol, 2003, 84 (3) ∶535-543.
    [8]Okamoto T, Omori H, Kaname Y, et al.A single-amino-acid mutation in hepatitis C virus NS5A disrupting FKBP8interaction im-pairs viral replication[J].J Virol.2008, 82 (7) ∶3480-3489.
    [8]Okamoto T, Omori H, Kaname Y, et al.A single-amino-acid mutation in hepatitis C virus NS5A disrupting FKBP8interaction im-pairs viral replication[J].J Virol.2008, 82 (7) ∶3480-3489.
    [9]Enomoto N, Sakuma L, Asahina Y, et al.Mutations in the nonstruc-tural protein5Agene and response to interferon in patients with chro-nic hepatitis C virus1b infection[J].N Engl J Med, 1996, 334∶77-81.
    [9]Enomoto N, Sakuma L, Asahina Y, et al.Mutations in the nonstruc-tural protein5Agene and response to interferon in patients with chro-nic hepatitis C virus1b infection[J].N Engl J Med, 1996, 334∶77-81.
    [10]Noguchi T, Satoh S, Noshi T, et al.Effects of mutation in hepatitis C virus nonstructural protein5A on interferon resistance mediated by inhibition of PKR kinase activity in mammalian cells[J].Microbi-ollmmunol, 2001, 45∶829-840.
    [10]Noguchi T, Satoh S, Noshi T, et al.Effects of mutation in hepatitis C virus nonstructural protein5A on interferon resistance mediated by inhibition of PKR kinase activity in mammalian cells[J].Microbi-ollmmunol, 2001, 45∶829-840.
    [11]Nousbaum JB, Polyak SJ, Ray SC, et al.Prospective characteriza-tion of full-length hepatitis C virus NS5Aquasispecies during induc-tion and combination antiviral therapy[J].J Virol, 2000, 74∶9028-9038.
    [11]Nousbaum JB, Polyak SJ, Ray SC, et al.Prospective characteriza-tion of full-length hepatitis C virus NS5Aquasispecies during induc-tion and combination antiviral therapy[J].J Virol, 2000, 74∶9028-9038.
    [12]Williams BR.Signal integration via PKR[J].SciSTKE, 2001, 89∶RE2.
    [12]Williams BR.Signal integration via PKR[J].SciSTKE, 2001, 89∶RE2.
    [13]Paterson M, Laxton CD, Thomas HC, et al.Hepatitis C virus NS5A protein inhibits inteferon antiviral activity, but the effects do not correlate with clinical response[J].Gastroenterology, 1999, 117∶1187-1197.
    [13]Paterson M, Laxton CD, Thomas HC, et al.Hepatitis C virus NS5A protein inhibits inteferon antiviral activity, but the effects do not correlate with clinical response[J].Gastroenterology, 1999, 117∶1187-1197.
    [14]Aizaki H, Saito S, Ogino T, et al.Suppression of interferon-in-duced antiviral activity in cells expressing hepatitis C virus proteins[J].J Interferon Cytokine Res, 2000, 20∶1111-1120.
    [14]Aizaki H, Saito S, Ogino T, et al.Suppression of interferon-in-duced antiviral activity in cells expressing hepatitis C virus proteins[J].J Interferon Cytokine Res, 2000, 20∶1111-1120.
    [15]Podevin P, Sabile A, Gajardo R, et al.Expression of hepatitis C virus NS5A natural mutants in a hepatocytic cell line inhibits the an-tiviral effect of interferon in a PKR-independent manner[J].Hepa-tology, 2001, 33∶1503-1511.
    [15]Podevin P, Sabile A, Gajardo R, et al.Expression of hepatitis C virus NS5A natural mutants in a hepatocytic cell line inhibits the an-tiviral effect of interferon in a PKR-independent manner[J].Hepa-tology, 2001, 33∶1503-1511.
    [16]Khabar KS, Al-Zoghaibi F, Al-Ahdal MN, et al.The chemo-kine, interleukin8, inhibits the antiviral action of interferonα[J].J Exp Med, 1997, 186∶1077-1085.
    [16]Khabar KS, Al-Zoghaibi F, Al-Ahdal MN, et al.The chemo-kine, interleukin8, inhibits the antiviral action of interferonα[J].J Exp Med, 1997, 186∶1077-1085.
    [17]Polyak S J, Khabar KS, Paschal DM, et al.Hepatitis C virus non-structural5A protein induces interleukin-8, leading to partial inhi-bition of the interferon-induced antiviral response[J].J Virol, 2001, 75∶6095-6106.
    [17]Polyak S J, Khabar KS, Paschal DM, et al.Hepatitis C virus non-structural5A protein induces interleukin-8, leading to partial inhi-bition of the interferon-induced antiviral response[J].J Virol, 2001, 75∶6095-6106.
    [18]Girard S, Shalhoub P, Lescure P, et al.An altered cellular re-sponse to interferon and up-regulation of interleukin-8induced by the hepatitis C viral protein NS5A uncovered by microarray analysis[J].Virology, 2002, 295∶272-283.
    [18]Girard S, Shalhoub P, Lescure P, et al.An altered cellular re-sponse to interferon and up-regulation of interleukin-8induced by the hepatitis C viral protein NS5A uncovered by microarray analysis[J].Virology, 2002, 295∶272-283.
    [19]Blindenbacher A, Duong FH, Hunziker L, et al.Expression of hepatitis C virus proteins inhibits interferon alpha signaling in the liv-er of transgenic mice[J].Gastroenterology, 2003, 24∶1465-1475.
    [19]Blindenbacher A, Duong FH, Hunziker L, et al.Expression of hepatitis C virus proteins inhibits interferon alpha signaling in the liv-er of transgenic mice[J].Gastroenterology, 2003, 24∶1465-1475.
    [20]Shuai K.Serine phosphorylation:arming Stat1against infection[J].Immunity, 2003, 19∶771-772.
    [20]Shuai K.Serine phosphorylation:arming Stat1against infection[J].Immunity, 2003, 19∶771-772.
    [21]Macdonald A, Crowder K, Street A, et al.The hepatitis C virus non-structural5A protein inhibits activating protein-1function by perturbing Ras-ERK pathway signaling[J].J Biol Chem, 2003, 278∶17775-17784.
    [21]Macdonald A, Crowder K, Street A, et al.The hepatitis C virus non-structural5A protein inhibits activating protein-1function by perturbing Ras-ERK pathway signaling[J].J Biol Chem, 2003, 278∶17775-17784.
    [22]Macdonald A, Crowder K, Street A, et al.The hepatitis C virus NS5A protein binds to members of the Src family of tyrosine kinases and regulates kinase activity[J].J Gen Virol, 2004, 85∶721-729.
    [22]Macdonald A, Crowder K, Street A, et al.The hepatitis C virus NS5A protein binds to members of the Src family of tyrosine kinases and regulates kinase activity[J].J Gen Virol, 2004, 85∶721-729.
    [23]Chang LF, Karin M.Mammalian MAP kinase signalling cascades[J].Nature, 2001, 410∶37-40.
    [23]Chang LF, Karin M.Mammalian MAP kinase signalling cascades[J].Nature, 2001, 410∶37-40.
    [24]Tan SL, Nakao H, He YP, et al.NS5A, a nonstructural protein of hepatitis C virus, binds growth factor receptor-bound protein2ada-ptor protein in a Src homology3domain/ligand-dependent manner and perturbs mitogenic signaling[J].Proc Natl Acad SciUSA, 1999, 96∶5533-5538.
    [24]Tan SL, Nakao H, He YP, et al.NS5A, a nonstructural protein of hepatitis C virus, binds growth factor receptor-bound protein2ada-ptor protein in a Src homology3domain/ligand-dependent manner and perturbs mitogenic signaling[J].Proc Natl Acad SciUSA, 1999, 96∶5533-5538.
    [25]Liu ZG, Hsu H, Goeddel DV, et al.Dissection of TNF receptor1effector functions:JNK activation is not linked to apoptosis while NF-B activation prevents cell death[J].Cell, 1996, 87∶565-576.
    [25]Liu ZG, Hsu H, Goeddel DV, et al.Dissection of TNF receptor1effector functions:JNK activation is not linked to apoptosis while NF-B activation prevents cell death[J].Cell, 1996, 87∶565-576.
    [26]Park KJ, Choi S, Choi DH, et al.Hepatitis C virus NS5A protein modulates c-Jun N-terminal kinase through interaction with tumor necrosis factor receptor-associated factor2[J].J Biol Chem, 2003, 278∶30711-30718.
    [26]Park KJ, Choi S, Choi DH, et al.Hepatitis C virus NS5A protein modulates c-Jun N-terminal kinase through interaction with tumor necrosis factor receptor-associated factor2[J].J Biol Chem, 2003, 278∶30711-30718.
    [27]He YP, Tan SL, Tareen SU, et al.Regulation of mRNAtranslation and cellular signaling by hepatitis C virus nonstructural protein NS5A[J].J Virol, 2001, 75∶5090-5098.
    [27]He YP, Tan SL, Tareen SU, et al.Regulation of mRNAtranslation and cellular signaling by hepatitis C virus nonstructural protein NS5A[J].J Virol, 2001, 75∶5090-5098.
    [28]Ghosh AK, Majumder M, Steele R, et al.Hepatitis C virus NSSa protein protects against TNF-αmediated apoptotic cell death[J].Virus Res, 2000, 67∶173-178.
    [28]Ghosh AK, Majumder M, Steele R, et al.Hepatitis C virus NSSa protein protects against TNF-αmediated apoptotic cell death[J].Virus Res, 2000, 67∶173-178.
    [29]Miyasaka Y, Enomoto NK, urosaki M, et al.Hepatitis C virus non-structural protein5A inhibits tumor necrosis factor-αmediated ap-optosis in Huh7cells[J].J Infect Dis, 2003, 188∶1537-1544.
    [29]Miyasaka Y, Enomoto NK, urosaki M, et al.Hepatitis C virus non-structural protein5A inhibits tumor necrosis factor-αmediated ap-optosis in Huh7cells[J].J Infect Dis, 2003, 188∶1537-1544.
    [30]Cory S, Adams Jm.The Bcl2family:regulators of the cellular life-or-death switch[J].Nat Rev Cancer, 2002, 2∶647-656.
    [30]Cory S, Adams Jm.The Bcl2family:regulators of the cellular life-or-death switch[J].Nat Rev Cancer, 2002, 2∶647-656.
    [31]Chung YL, Sheu ML, Yen SH.Hepatitis C virus NS5Aas a poten-tial viral Bcl-2homologue interacts with Bax and inhibits apoptosis in hepatocellular carcinoma[J].Int J Cancer, 2003, 107∶65-73.
    [31]Chung YL, Sheu ML, Yen SH.Hepatitis C virus NS5Aas a poten-tial viral Bcl-2homologue interacts with Bax and inhibits apoptosis in hepatocellular carcinoma[J].Int J Cancer, 2003, 107∶65-73.
    [32]Satoh S, Hirota M, Noguchi T, et al.Cleavage of hepatitis C virus nonstructural protein5A by a caspase-like ptoteases in mammalian cells[J].Virology, 2000, 270∶476-487.
    [32]Satoh S, Hirota M, Noguchi T, et al.Cleavage of hepatitis C virus nonstructural protein5A by a caspase-like ptoteases in mammalian cells[J].Virology, 2000, 270∶476-487.
    [33]Majumder M, Ghosh AK, Steele R, et al.Hepatitis C virus NS5A physically associaticates with p53and regulates p21/wafl gene ex-pression in a p53-dependent manner[J].J Virol, 2001, 75∶1401-1407.
    [33]Majumder M, Ghosh AK, Steele R, et al.Hepatitis C virus NS5A physically associaticates with p53and regulates p21/wafl gene ex-pression in a p53-dependent manner[J].J Virol, 2001, 75∶1401-1407.
    [34]Robinson LC, Marchant JS.Enhanced Ca2+leak from ER Ca2+stores induced by hepatitis C NS5A protein[J].Biochem Biophys Res Commun.2008, 368 (3) ∶593-599.
    [34]Robinson LC, Marchant JS.Enhanced Ca2+leak from ER Ca2+stores induced by hepatitis C NS5A protein[J].Biochem Biophys Res Commun.2008, 368 (3) ∶593-599.
    [35]龚国忠, Aleem Siddiqui, 苏先狮.丙型肝炎病毒非结构蛋白5a对细胞周期的影响[J].中华肝脏病杂志, 2004, 12 (1) ∶47-48.
    [35]龚国忠, Aleem Siddiqui, 苏先狮.丙型肝炎病毒非结构蛋白5a对细胞周期的影响[J].中华肝脏病杂志, 2004, 12 (1) ∶47-48.
    [36]Inubushi S, Nagano-Fujii M, Kitayama K, et al.Hepatitis C vi-rus NS5Aprotein interacts with and negatively regulates the non-re-ceptor protein tyrosine kinase Syk[J].J Gen Virol, 2008, 89 (Pt5) ∶1231-1242.
    [36]Inubushi S, Nagano-Fujii M, Kitayama K, et al.Hepatitis C vi-rus NS5Aprotein interacts with and negatively regulates the non-re-ceptor protein tyrosine kinase Syk[J].J Gen Virol, 2008, 89 (Pt5) ∶1231-1242.
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