-
摘要: 目的了解HBV相关肝细胞癌患者乙型肝炎病毒基因型别及分布特点。方法采用聚合酶链式反应结合Taqman MGB探针技术对70例HCC患者和57例CHB患者进行HBV基因分型检测和分析。结果HCC患者中C基因型占74.29%,B基因型占24.29%%,BC基因型占5.71%。HCC患者C基因型所占比例显著高于CHB患者(P<0.05)。HCC(40~50)岁年龄组和50岁以上年龄组患者中B基因型分别占16.67%、28.57%;C基因型分别占83.33%、68.57%,两年龄组患者B、C基因型分布均无明显差异(P均>0.05)。HCC B、C基因型患者的血清HBeAg阳性率、HBeAb阳性率、e系统(HBeAg HBeAb)阴性率及HBVDNA水平差异均无显著性(P均>0.05)。结论南京地区HBV相关HCC患者HBV基因型以C型为主,其次为B型,少量为BC混合型。HCC患者的基因型与发病年龄之间无明显相关性。HCC B、C基因型患者的HBeAg表达状态以及HBVDNA复制水平均无明显差异。
-
[1]Thakur V, Guptan R C, Kazim SN, et al.Profile, sepectrum and sig-nificance of HBVgenotypes in chronic liver disease patients in the In-dian subcontinent[J].J Gastroenterol Hepatol, 2002, 17 (2) ∶165-170. [1]Thakur V, Guptan R C, Kazim SN, et al.Profile, sepectrum and sig-nificance of HBVgenotypes in chronic liver disease patients in the In-dian subcontinent[J].J Gastroenterol Hepatol, 2002, 17 (2) ∶165-170. [2] 中国抗癌协会肝癌专业委员会.原发性肝癌诊断标准[J].中华肝脏病杂志, 2000, 8∶135. [2] 中国抗癌协会肝癌专业委员会.原发性肝癌诊断标准[J].中华肝脏病杂志, 2000, 8∶135. [3] 中华医学会.病毒性肝炎防治方案[J].中华内科杂志, 2000, 40 (1) ∶62~68. [3] 中华医学会.病毒性肝炎防治方案[J].中华内科杂志, 2000, 40 (1) ∶62~68. [4]Ding X, Mzokami M, Yao G, et, al.Hepatitis B virus genotype distri-bution among chronic hepatitis B virus carriers in shanghai, china[J].Interviology, 2001, 44 (1) ∶43-47. [4]Ding X, Mzokami M, Yao G, et, al.Hepatitis B virus genotype distri-bution among chronic hepatitis B virus carriers in shanghai, china[J].Interviology, 2001, 44 (1) ∶43-47. [5]Orito E, Ichida T, Sakugawa H, et al.Geographic distribution of hep-atitis B virus genotype in patients with chronic HBV infection in Ja-pan[J].Hepatology, 2001, 34 (3) ∶590-594. [5]Orito E, Ichida T, Sakugawa H, et al.Geographic distribution of hep-atitis B virus genotype in patients with chronic HBV infection in Ja-pan[J].Hepatology, 2001, 34 (3) ∶590-594. [6]kao JH, Wu NH, chen PJ, et aL.Hepatitis B genotypes and the re-sponse to interferon therapy[J].Hepatol, 2000, 33∶998-1002. [6]kao JH, Wu NH, chen PJ, et aL.Hepatitis B genotypes and the re-sponse to interferon therapy[J].Hepatol, 2000, 33∶998-1002. [7]Lindh M, Hannoun C, Dhillon AP, et al.Core promoter mutations and genotypes in relation to viral replication and liver damage in East Asi-an hepatitis B virus carriers[J].J Infect Dis, 1999, 179 (4) ∶775-782. [7]Lindh M, Hannoun C, Dhillon AP, et al.Core promoter mutations and genotypes in relation to viral replication and liver damage in East Asi-an hepatitis B virus carriers[J].J Infect Dis, 1999, 179 (4) ∶775-782. [8]谢琴秀, 许家璋, 李平, 等.江苏地区乙型肝炎病毒基因分型及其临床意义[J].疾病控制杂志, 2005, 9 (2) ∶171-173. [8]谢琴秀, 许家璋, 李平, 等.江苏地区乙型肝炎病毒基因分型及其临床意义[J].疾病控制杂志, 2005, 9 (2) ∶171-173.
本文二维码
计量
- 文章访问数: 2055
- HTML全文浏览量: 8
- PDF下载量: 759
- 被引次数: 0