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摘要: 目的观察42例重型肝炎患者经人工肝血浆置换治疗后的转归,探讨人工肝血浆置换治疗重型肝炎的临床效果。方法42例患者在常规药物治疗基础上联合血浆置换治疗,设对照组32例常规药物治疗,比较血浆置换组和对照组治疗效果,同时观察血浆置换后的不良反应。结果42例患者血浆置换后临床症状有明显好转,ALT、AST、TBil、Cr均降低(P<0.05),CHE、PTA均升高(P<0.05),对照组常规治疗一周后,ALT、AST、TBil、Cr、CHE、PTA无明显改变(P>0.05);42例患者最终基本治愈出院36例(85.72%),死亡6例(14.28%),与对照组相比,病死率明显下降(P<0.05);血浆置换78例次后仅有10例次出现不良反应,总发生率为12.82%。结论人工肝血浆置换能有效地改善患者的临床症状和主要实验室指标,降低了重型肝炎的病死率,且不良反应少,对重型肝炎有肯定和可靠的辅助支持与治疗作用。
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