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Analysis of risk factors of type 2 diabetes in patients with Nonalcoholic fatty liver disease
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摘要: 目的探讨非酒精性脂肪肝(NAFLD)患者发生2型糖尿病的危险因素。方法选择38例非酒精性脂肪肝伴初诊2型糖尿病(DFL)患者,并与26例非酒精性脂肪肝(NAFLD)患者进行比较,对两组的相关变量进行多因素Logistic回归分析。结果27个变量中,单因素Logistic回归分析显示糖尿病家族史、体重指数、业余锻炼、婚姻状况、脂肪肝病程、甜食、甘油三酯、载脂蛋白A1、空腹胰岛素、餐后2小时胰岛素、C肽(CP)、胰岛素抵抗指数、空腹血糖、餐后2小时血糖在两组间差异有显著性;多因素Logistic回归分析显示家族关系、业余锻炼、甜食、甘油三酯、载脂蛋白A1、餐后2小时胰岛素、空腹血糖及餐后2h血糖具有统计学意义。结论糖尿病家族史、甜食、高甘油三酯、高载脂蛋白A1及餐后2小时胰岛素降低是非酒精性脂肪肝患者发生2型糖尿病危险因素,而业余锻炼是其保护因素。
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关键词:
- 2型糖尿病 /
- 非酒精性脂肪肝 /
- 危险因素 /
- Logistic回归分析
Abstract: Objective To explore risk factors of type 2 diabetes in patients with Nonalcoholic fatty liver disease.Methods The data of 38 cases of Nonalcoholic fatty liver disease with type 2 diabetes were collected in our hospital from 2006.1 to 2008 1, 26 cases of Nonalcoholic fatty liver disease were selccteg randomly as control during the same period.The associated variable were analyzed by using logistic regression model.Results Family history, exercise, sugar food, triglycerids (TG) , APOA1 and 2h insulin had statistic significance.Conclusion Family history, sugar food, high serum triglycerids (TG) , high serum APOA1 and low 2 h insulin were the main risk factors forming type 2 Diabetes in nonalcoholic fatty liver patients, while appropriate exercise is a protective factor. -
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