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The valuable tumormarkers of CEA and CA19-9 in the bile for diagnosis of cholangiocarcinoma and carcinoma of ampulla
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摘要: 目的探讨胆汁CEA、CA19-9联合检测对肝外胆管癌及壶腹癌诊断价值。方法观察组38例肝外胆管癌及壶腹癌患者在行ERCP检查前检测血清CEA及CA19-9,行ERCP检查时经造影导管抽取胆汁5ml用放免方法检测CEA及CA19-9,同时在导丝引导下自胆管咬取活检行病理检查,并记录影像学特征;同样,对照组30例非恶性病变患者在行ERCP检查时抽取5ml胆汁检测CEA及CA19-9。结果观察两组患者胆汁CA19-9、CEA水平明显高于对照组,有统计学意义（P<0.05）,与病理结果一致;观察组患者胆汁及血清CA19-9水平比较,有统计学差异（P<0.05）,而CEA水平无明显差异（P>0.05）。结论胆汁CEA、CA19-9联合检测对肝外胆管癌及壶腹癌的定性诊断有重要临床价值。Abstract: Objective To determine the valuable tumormarkers of CEA and CA19-9 in the bile for diagnosis of cholangiocarcinoma and carcinoma of ampulla.Methods Serum CEA and CA19-9 were detected by radio immunoassay in 38 patients of observation group with cholangiocarcinoma and carcinoma of ampulla before endoscopic retragrade cholangiopancreatography (ERCP) , took 5ml bile to detecte CEA and CA 19-9 While ERCP, and took endoscopic biopsy for histopathological with the help of wise, recorded the feature of imaging.Bile CEA and CA19-9 were detected in 30 patients with unmalignant of contrast group in the same way.Results There were significance in the bile level of CEA or CA 19-9 between the two groups (P<0.05) , it is coincide to the histopathological.There were significance in the level of CA 19-9 between the bile and the serum (P<0.05) , but no significance in the level of CEA (P>0.05) .Conclusion The tumormarkers of CEA and CA19-9 in the bile for diagnosis of cholangiocarcinoma and carcinoma of ampulla have important valuable.
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Key words:
- Cholangiocarcinoma /
- Carcinoma of ampulla /
- bile /
- CEA /
- CA19-9
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