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自身免疫性肝炎患者血清中高迁移率族蛋白B1检测及临床意义

赵擎 辛绍杰 侯俊 胡燕 貌盼勇

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自身免疫性肝炎患者血清中高迁移率族蛋白B1检测及临床意义

详细信息
  • 中图分类号: R575.1;R446.6

Detection high mobility group box-1 protein in autoimmune hepatitis

  • 摘要: 目的采用ELISA检测方法,初步探讨人高迁移率族蛋白B1(HMGB1)与自身免疫性肝炎(AIH)发病的相互作用关系。方法将纯化的HMGB1蛋白,包被ELISA检测微孔板,检测AIH患者和健康献血员的血清分别165份和69份,分析比较AIH患者和健康献血员的血清中抗HMGB1抗体的分泌情况。结果AIH患者血清中抗HMGB1抗体的阳性率明显高于健康献血员(78.7%VS50.7%,P<0.05)。直线回归分析显示,抗HMGB1抗体滴度(OD值)与ALT水平有很好的相关性(相关系数r=0.968)。结论HMGB1是AIH疾病发生发展中一个重要的炎症蛋白,与疾病的炎症活动程度有很好的相关性。

     

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  • 出版日期:  2009-02-20
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