Signal transduction during hepatic stellate cell proliferation and possible therapeutic targets against hepatic fibrosis
-
-
[1]Borkham-Kamphorst E, Herrmann J, Stoll D, et al.Dominant-negative soluble PDGf-beta receptor inhibits hepatic stellate cell ac-tivation and attenuates liver fibrosis[J].Lab Invest, 2004, 84 (6) ∶766-777. [2]Breitkopf K, Roeyen C, Sawitza I, et al.Expression patterns ofPDGf-A, -B, -C and-D and the PDGF-receptors alpha andbeta in activated rat hepatic stellate cells (HSC) [J].Cytokine, 2005, 31 (5) ∶349-357. [3]Pinzani M, Marra F, Carloni V.Signal transduction in hepatic stel-late cells[J].Liver, 1998, 18 (1) ∶2-13. [4]Reeves HL, Thompson MG, Dack CL, et al.The role of phosphatid-ic acid in platelet-derived growth factor-induced proliferation of rathepatic stellate cells[J].Hepatology, 2000, 31 (1) ∶95-100. [5]Marra F, Arrighi MC, Fazi M, et al.Extracellular signal-regulatedkinase activation differentially regulates platelet-derived growth fac-tor's actions in hepatic stellate cells, and is induced by in vivo liverinjury in the rat[J].Hepatology, 1999, 30 (4) ∶951-958. [6]Pinzani M.PDGF and signal transduction in hepatic stellatecells[J].Front Biosci, 2002, 7∶d1720-d1726. [7]Reif S, Lang A, Lindquist JN, et al.The role of focal adhesion ki-nase-phosphatidylinositol 3-kinase-akt signaling in hepatic stel-late cell proliferation and type I collagen expression[J].J BiolChem, 2003, 278 (10) ∶8083-8090. [8]Caligiuri A, De Franco RM, Romanelli RG, et al.Antifibrogeniceffects of canrenone, an antialdosteronic drug, on human hepaticstellate cells[J].Gastroenterology, 2003, 124 (2) ∶504-520. [9]Zhou Y, Zheng S, Lin J, et al.The interruption of the PDGF andEGF signaling pathways by curcumin stimulates gene expression ofPPARgamma in rat activated hepatic stellate cell invitro[J].Lab In-vest, 2007, 87 (5) ∶488-498. [10]Gabele E, Reif S, Tsukada S, et al.The role of p70S6Kin hepaticstellate cell collagen gene expression and cell proliferation[J].J BiolChem, 2005, 280 (14) ∶13374-13382. [11]Carloni V, Pinzani M, Giusti S, et al.Tyrosine phosphorylation offocal adhesion kinase by PDGF is dependent on ras in human hepaticstellate cells[J].Hepatology, 2000, 31 (1) ∶131-140. [12]Carloni V, Defranco RM, Caligiuri A, et al.Cell adhesion regu-lates platelet-derived growth factor-induced MAP kinase and PI-3 kinase activation in stellate cells[J].Hepatology, 2002, 36 (3) ∶582-591. [13]Di Sario A, Bendia E, Taffetani S, et al.Selective Na+/H+ex-change inhibition by cariporide reduces liver fibrosis in the rat[J].Hepatology, 2003, 37 (2) ∶256-266. [14]Mallat A, Gallois C, Tao J, et al.Platelet-derived growth factor-BB and thrombin generate positive and negative signals for humanhepatic stellate cell proliferation.Role of a prostaglandin/cyclic AMPpathway and cross-talk with endothelin receptors[J].J Biol Chem, 1998, 273 (42) ∶27300-27305. [15]Koide S, Kobayashi Y, Oki Y, et al.Prostaglandin E2 inhibitsplatelet-derived growth factor-stimulated cell proliferation througha prostaglandin E receptor EP2 subtype in rat hepatic stellatecells[J].Dig Dis Sci, 2004, 49 (9) ∶1394-1400. [16]Failli P, De Franco RM, Caligiuri A, et al.Nitrovasodilators inhib-it platelet-derived growth factor-induced proliferation and migra-tion of activated human hepatic stellate cells[J].Gastroenterology, 2000, 119 (2) ∶479-492. [17]Bataller R, Gabele E, Parsons CJ, et al.Systemic infusion of an-giotensinⅡexacerbates liver fibrosis in bile duct-ligated rats[J].Hepatology, 2005, 41 (5) ∶1046-1055. [18]Bataller R, Schwabe RF, Choi YH, et al.NADPH oxidase signaltransduces angiotensinⅡin hepatic stellate cells and is critical inhepatic fibrosis[J].J Clin Invest, 2003, 112 (9) 0∶1383-1394. [19]Liu J, Gong H, Zhang ZT, et al.Effect of angiotensinⅡand an-giotensinⅡtype 1 receptor antagonist on the proliferation, contrac-tion and collagen synthesis in rat hepatic stellate cells[J].Chin MedJ (Engl) , 2008, 121 (2) ∶161-165. [20]Saxena NK, Titus MA, Ding X, et al.Leptin as a novel profibro-genic cytokine in hepatic stellate cells:mitogenesis and inhibition ofapoptosis mediated by extracellular regulated kinase (Erk) and Aktphosphorylation[J].FASEB J, 2004, 18 (13) ∶1612-1614. [21]Lang T, Ikejima K, Yoshikawa M, et al.Leptin facilitates prolifer-ation of hepatic stellate cells through up-regulation of platelet-de-rived growth factor receptor[J].Biochem Biophys Res Commun, 2004, 323 (3) ∶1091-1095. [22]Ahima RS, Osei SY.Leptin signaling[J].Physiol Behav, 2004, 81 (2) ∶223-241. [23]Yang L, Chan CC, Kwon OS, et al.Regulation of peroxisome pro-liferator-activated receptor-gamma in liver fibrosis[J].Am J Phys-iol Gastrointest Liver Physiol, 2006, 291 (5) ∶G902-G911. [24]Hellemans K, Michalik L, Dittie A, et al.Peroxisome proliferator-activated receptor-beta signaling contributes to enhanced prolifer-ation of hepatic stellate cells[J].Gastroenterology, 2003, 124 (1) ∶184-201. [25]Hazra S, Xiong S, Wang J, et al.Peroxisome proliferator-activa-ted receptor gamma induces a phenotypic switch from activated toquiescent hepatic stellate cells[J].J Bioi Chem, 2004, 279 (12) ∶11392-11401. [26]Lin J, Chen A.Activation of peroxisome proliferator-activated re-ceptor-gamma by curcumin blocks the signaling pathways for PDGFand EGF in hepatic stellate cells[J].Lab Invest, 2008, 88 (5) ∶529-540. [27]Shyy JY, Chien S.Role of integrins in endothelial mechanosensingof shear stress[J].Circ Res, 2002, 91 (9) ∶769-775. [28]Zhou X, Jamil A, Nash A, et al.Impaired proteolysis of collagen Iinhibits proliferation of hepatic stellate cells:implications for regula-tion of liver fibrosis[J].J Biol Chem, 2006, 281 (52) ∶39757-39765. [29]Zhou X, Murphy FR, Gehdu N, et al.Engagement of alphavbeta3integrin regulates proliferation and apoptosis of hepatic stellatecells[J].J Biol Chem, 2004, 279 (23) ∶23996-24006.
本文二维码
计量
- 文章访问数: 3365
- HTML全文浏览量: 6
- PDF下载量: 1142
- 被引次数: 0