Abstract: Objective To investigate the correlation between the risk factors and prognosis of chronic hepatic failure.Methods We selected 28 patients with chronic hepatic failure in our Department of Infection Diseases from June 2007 to January 2008.The patients were divided into improved group and exacerbation group.We review the data of age;complications like:ascites, primary bacterial peritonitis, digestive tract hemorrhage, hepatocerebral disease, hepatorenal syndrome;laboratory examinations like:prothrombin time (PT) , prothrombin time activity (PTA) , International ratio (INR) , blood coagulation factor V (FV:C) , fibrinogen (FIB) , D-dimer (D-D) , total cholesterol (TC) , total bilirubin (TBil) , albumin (ALB) , prealbumin (PRE-A) , alanine aminotransferase (ALT) , Blood urea (BUN) , serum creatinine (SCR) , blood platelet (PLT) .Analyze the index above with SPSS 10.0 by logistic regression.Results total cholesterol (TC) , blood coagulat on factor V (FV:C) and ascites were significantly different between the two groups (P<0.05) .Conclusion TC, F V:C and ascites are valuable in predicting patients with chronic hepatic failure.