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The clinical study of TACE combined with endogenetic field tumor hyperthermia system in treatment of primary hepatic carcinoma.
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摘要: 目的评价肝动脉化疗栓塞术(TACE)联合内生场热疗治疗原发性肝癌的有效性和安全性。方法46例原发性肝癌患者随机分成两组,治疗组和对照组。对照组采用阿霉素、丝裂霉素、5氟尿嘧啶和栓塞剂(碘化油、明胶海绵)行肝动脉化疗栓塞治疗,治疗组除上述治疗外同时加用内生场热疗(每周二次)。根据WHO标准评价近期客观疗效及其毒性。结果治疗组与对照组的有效率分别为69.6%与39.1%,有差异显著(P<0.05)。中位生存期分别为14个月和8个月,1年生存率为65.2%和34.8%。毒副反应较轻,主要为Ⅰ、Ⅱ度的骨髓抑制及消化道反应,偶有发热,治疗组低于对照组。结论热疗联合肝动脉化疗栓塞术(TACE),可增强疗效,提高生存率、减轻毒副作用,安全可靠。Abstract: Objective To investigate the efficacy and safety of TACE combined with hyperthermia with endogenetic field tumor hyperthermia system in treatment of primary hepatic carcinoma.Methods 46 patients with HPC were randomly divided into two groups.The observed group (23 patients) was treated with ADM, 5-FU, MMC and combined with hyperthermia.The control group (23patients) was treated with the same drugs except hyperthermia.Results The efficacy of the observed group and the control group were 69.6% and 39.1% respectively.There was significant difference between them (P<0.05) .The side effects were little and the main side effects included myelosuppression (Ⅰ-Ⅱ degree) , gastrointestinal reactions, and the side effects in the observed group was less than the control group.The average life span were 14 months and 8 months, the survival in 1 year were 65.2% and 34.8% respectively (P<0.05) .Conclusion The treatment of TACE combined with hyperthermia can enhance the therapy effect and survivval and reduce the side effect, it also was a safe and effective treatment.
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Key words:
- hyperthermia /
- primary hepatic carcinoma (HPC) /
- hepaticartery
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