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胆囊良恶性病变组织中神经生长因子(NGF)及其mRNA表达的临床病理意义研究

杨晓静 杨竹林 黄江生 杨乐平 付汐

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胆囊良恶性病变组织中神经生长因子(NGF)及其mRNA表达的临床病理意义研究

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  • 中图分类号: R575.6

Study on pathological significance in the expression of the nerve growth factor (NCF) and its mRNA in benign and malignant lesions of gallbladder.

  • 摘要: 目的研究胆囊良恶性病变组织中NGF及其mRNA表达水平和临床病理意义。方法108例胆囊腺癌、46例癌旁组织和35例慢性胆囊炎标本常规石蜡包埋切片,NGF染色方法为En VisiomTM免疫组化法,NGFmR-NA染色方法为原位杂交法。结果胆囊腺癌NGF和NGFmRNA表达阳性率及其评分明显高于癌旁组织和慢性胆囊炎组织(P<0.01);腺瘤癌变或高分化腺癌、肿块最大径<2cm、无淋巴结转移和未侵犯周围组织病例NGF和NGFmRNA表达阳性率及其评分明显低于低分化腺癌、肿块最大径≥2cm、淋巴结转移及侵犯周围组织病例(P<0.05或P<0.01)。结论NGF及其mRNA表达水平可能与胆囊腺癌发生、进展、侵袭有密切关系,可能是反映胆囊癌预后的重要生物学标记物。

     

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  • 出版日期:  2008-03-20
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