Abstract: Objective To investigate the therapeutic effects of compound glycyrrhizin liposome on rats with nonalcoholic steatohepatitis.Methods 35 male SD rats were randomly divided into 4 groups: the model group (n=10) 、compound glycyrrhizin control group (n=10) and compound glycyrrhizin liposome treated group (n=10) all were fed with fat-rich diet, and the normal group (n=5) with normal diet.Drug was given to each group after 8th week, all rats were sacrificed at 16 th week.The serum levels of ALT、AST and GGT were measured with auto-biochemistry instrument.The hepatic histologic scores on fat-liver and inflammation of NASH were done according to the guidelines of the diagnosis and treatment of NAFLD in February 2006.Results Compared with model group, the blood-serum levels of AST reduced significantly in treated group (P<0.05) , the blood-serum levels of GGT and hepatic histologic scores on inflammation of NASH both reduced remarkably in treated group (P<0.01) ;Compared with control group, the hepatic histologic scores on inflammation of NASH and the blood-serum levels of GGT both reduced remarkably in treated group (P<0.01) .Conclusion Compound glycyrrhizin liposome is effective in treatment of steatohepatitic rats induced by fat-rich diet.