ALT小于2×ULN慢性乙型肝炎患者的肝组织病理学分析

李静; 刘素芬; 叶立红; 杜瑞清; 卢建华; 来家琪

ALT小于2×ULN慢性乙型肝炎患者的肝组织病理学分析

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中图分类号: R512.6
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出版历程
- 出版日期: 2008-03-20

Pathological characterization of the chronic hepatitis B with ALT less than 2×ULN/L

摘要

摘要: 目的观察ALT小于2×ULN慢性乙型肝炎患者的肝组织病理学与ALT的相关性。方法选择符合诊断标准的303例慢性乙型肝炎患者,检测血清肝功能、进行肝脏活检,肝脏组织标本进行常规病理检测。结果ALT小于2×ULN慢性乙型肝炎患者肝组织64.68%有2级以上的炎症改变,56.44%有2期以上的纤维化。本组中ALT男性均值为(39.73±19.14)U/L,女性为(29.21±13.90)U/L。结论ALT与炎性分级、纤维化分期均有相关性。ALT正常与不正常的慢性乙型肝炎患者肝脏组织炎性分级、纤维化分期不同,随着ALT数值的升高肝组织炎症及纤维化改变越明显。
- 乙型肝炎 /
- 丙氨酸氨基转移酶 /
- 肝组织病理
Abstract: Objective To analyze the relationships between alanine aminotransferase (ALT) and hepatic histopathology in chronic hepatitis B (CHB) patients with ALT2×ULN/L.Methods 303 patients with the diagnosis of CHB, the liver functions were tested and the pathological changes were shown by liver biopsy.Results The inflammatory grade was at 2 stage or higher in 64.68% of patients and the hepatic fibrosis degree were at 2 stage and higher in 56.44% of patients.The relationship between ALT and inflammatory grade/fibrotic stage was positive correlation.Conclusion There were differences of inflammatory grade/fibrotic stage between patients with normal ALT and patients with abnormal ALT.The inflammatory and fibrosis in liver progressed along with the increasing of ALT.
- chronic hepatic B /
- ALT /
- hepatic histopathology

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参考文献(6)

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