肝纤维化基因治疗的研究进展

齐晓艳; 高润平

肝纤维化基因治疗的研究进展

基金项目:

吉林省自然科学基金资助项目(No.200505211)；国际合作项目(No.20070729-9)；

详细信息

中图分类号: R575.2
计量
- 文章访问数: 2895
- HTML全文浏览量: 9
- PDF下载量: 978
- 被引次数: 0
出版历程
- 出版日期: 2008-02-20

Research funding:

摘要

HTML全文

参考文献(20)

[1]Bataller R, Brenner DA. Liver fibrosis[J].J Clin Invest, 2005, 115∶209-218.

[2]Friedman SL. Arthur MJ. Reversing hepatic fibrosis[J].Sci Med, 2002, 8∶194-205.

[3]Wei J, Yang CQ, Liu WB, et al. Blockage of transforming growth factor receptors prevents progression of pig serum-induced rat liver fibrosis[J].J World Gastroenterol, 2004, 10 (11) ∶1634-1638.

[4]Kinoshita K, Iimuro Y, Otogawa K, et al. Adenovirus-mediated expression of BMP-7 suppresses the development of liver fibrosis in rats[J].Gut, 2007, 56 (5) ∶706-714.

[5]Borkham-Kamphorst E, Stoll D, Gressner AM, et al. Inhibitory effect of soluble PDGF-beta receptor in culture-activated hepatic stellate cells[J].Biochem Biophys Res Commun, 2004, 317∶451-462.

[6]Borkham-Kamphorst E, Stoll D, Gressner AM, et al.Antisensestrategy against PDGF B-chain proves effective in preventing experi-mental liver fibrogenesis[J].Biochem Biophys Res Commun, 2004, 321∶413-423.

[7]Saxena NK, Titus MA, Ding X.Leptin as a novel profibrogenic cyto-kine in hepatic stellate cells:mitogenesis and inhibition of apoptosismediated by extracellular regulated kinase (Erk) and Akt phospho-rylation[J].FASEB J, 2004, 18 (13) ∶1612-1614.

[8]Xue XL, Lin JS.RNAinterference targeting leptin gene effect on he-patic stellate cells[J].J Huazhong Univ Sci Technolog Med Sci, 2005, 25∶655-657.

[9]Iimuro Y, Fujimoto J. Strategy of gene therapy for liver cirrohosis and hepatocellular carcinoma[J].Hepatobiliary Pancreat Surg, 2003, 10 (1) ∶45-47.

[10]Lin Y, XIE WF, Chen YX, et al.Treatment of experimental hepat-ic fibrosis by combinational delivery of urokinase-type Plaminogenactivator and hepatocyte growth factor genes[J].Liver Int, 2005, 25 (4) ∶796-807.

[11]Tanigawa K, Sakaida I, Masuhara M, et al.Augmenter of liver re-generation (ALR) may promote liver regeneration by reducing natu-ral killer (NK) cell activity in human liver disease[J].J Gastroen-terol, 2000, 35∶112-119.

[12]Gressner AM, Weiskirchen R, Breitkopf K, et al. Roles of TGF-β in hepatic fibrosis[J].Front Biosci , 2002, 7∶d793-807.

[13]Roderfeld M, Weiskirchen R, Waqner S, et al.Inhibition of hepat-ic fibrogensis by matrix metalloproteinase-9 mutants in mice[J].FASEB J.2006, 20 (3) ∶444-454.

[14]Iimuro Y, Nishio T, Morimoto T, et al.Delivery of matrix metallo-proteinase-1 attenuates established liver fibrosis in the rat[J].JGastroenterology, 2003, 124 (2) ∶445-458.

[15]Hu YB, Li DG, Lu HM. Modified synthetic siRNA targeting tissue inhibitor of metalloproteinase-2 inhibits hepatic fibrogenesis in rats[J].J Gene Med, 2007, 9 (3) ∶217-229.

[16]Asadullah K, Sterry W, Volk HD. Interleukin-10 therapy: review of a new approach[J].Pharmacol Rev, 2003, 55∶241-269.

[17]Chou WY, Lu CN, Lee TH, et al. Electroporative interleukin-10 gene transfer ameliorates carbon tetrachloride-induced murine liver fibrosis by MMP and TIMP modulation[J].J Acta Pharmacol Sin, 2006k, 27 (4) ∶469-476.

[18]Chen M, Wang GJ, Diao Y, et al.Adeno-associated virus media-ted interferon-gamma inhibits the progression of hepatic fibrosis invitro and in vivo[J].World J Gastrornterol, 2005, 11 (26) ∶4045-4051.

[19]Wang CH, Lee TH, Lu CN, et al.Electroporative alpha-MSHgene transfer attenuates thioacetamide-induced murine hepatic fi-brosis by MMP and TIMP modulation[J].J Gene Ther, 2006, 13 (13) ∶1000-1009.

[20]Tsuruta S, Nakamuta M, Enjoji M, et al.Anti-monocyte che-moattractant protein-1 gene therapy prevents dimethynitrosaminein-duced hepatic fibrosis in rats[J].Int J Mol Med, 2004, 14 (5) ∶837-842.

施引文献

资源附件(0)

访问统计