肝纤维化基因治疗的研究进展

齐晓艳; 高润平

肝纤维化基因治疗的研究进展

基金项目:

吉林省自然科学基金资助项目(No.200505211)；国际合作项目(No.20070729-9)；

详细信息

中图分类号: R575.2
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出版历程
- 出版日期: 2008-02-20

Research funding:

摘要

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参考文献(20)

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[10]Lin Y, XIE WF, Chen YX, et al.Treatment of experimental hepat-ic fibrosis by combinational delivery of urokinase-type Plaminogenactivator and hepatocyte growth factor genes[J].Liver Int, 2005, 25 (4) ∶796-807.

[11]Tanigawa K, Sakaida I, Masuhara M, et al.Augmenter of liver re-generation (ALR) may promote liver regeneration by reducing natu-ral killer (NK) cell activity in human liver disease[J].J Gastroen-terol, 2000, 35∶112-119.

[12]Gressner AM, Weiskirchen R, Breitkopf K, et al. Roles of TGF-β in hepatic fibrosis[J].Front Biosci , 2002, 7∶d793-807.

[13]Roderfeld M, Weiskirchen R, Waqner S, et al.Inhibition of hepat-ic fibrogensis by matrix metalloproteinase-9 mutants in mice[J].FASEB J.2006, 20 (3) ∶444-454.

[14]Iimuro Y, Nishio T, Morimoto T, et al.Delivery of matrix metallo-proteinase-1 attenuates established liver fibrosis in the rat[J].JGastroenterology, 2003, 124 (2) ∶445-458.

[15]Hu YB, Li DG, Lu HM. Modified synthetic siRNA targeting tissue inhibitor of metalloproteinase-2 inhibits hepatic fibrogenesis in rats[J].J Gene Med, 2007, 9 (3) ∶217-229.

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[17]Chou WY, Lu CN, Lee TH, et al. Electroporative interleukin-10 gene transfer ameliorates carbon tetrachloride-induced murine liver fibrosis by MMP and TIMP modulation[J].J Acta Pharmacol Sin, 2006k, 27 (4) ∶469-476.

[18]Chen M, Wang GJ, Diao Y, et al.Adeno-associated virus media-ted interferon-gamma inhibits the progression of hepatic fibrosis invitro and in vivo[J].World J Gastrornterol, 2005, 11 (26) ∶4045-4051.

[19]Wang CH, Lee TH, Lu CN, et al.Electroporative alpha-MSHgene transfer attenuates thioacetamide-induced murine hepatic fi-brosis by MMP and TIMP modulation[J].J Gene Ther, 2006, 13 (13) ∶1000-1009.

[20]Tsuruta S, Nakamuta M, Enjoji M, et al.Anti-monocyte che-moattractant protein-1 gene therapy prevents dimethynitrosaminein-duced hepatic fibrosis in rats[J].Int J Mol Med, 2004, 14 (5) ∶837-842.

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