c-myb在肝细胞癌组织中的表达及临床意义

张荣贵; 汤正好; 冯洁; 臧国庆; 余永胜

c-myb在肝细胞癌组织中的表达及临床意义

详细信息

中图分类号: R735.7
计量
- 文章访问数: 2345
- HTML全文浏览量: 20
- PDF下载量: 901
- 被引次数: 0
出版历程
- 出版日期: 2008-02-20

The expression of c-myb in HCC tissues and clinical significance.

摘要

摘要: 目的研究c-myb基因在HCC组织中的表达,探讨其在HCC发生、发展中的作用及临床意义。方法应用免疫组织化学法检测55例HCC组织、55例癌旁组织、12例肝硬化组织和11例正常肝组织中c-myb蛋白表达情况。结果癌组织相对于正常的肝组织,癌旁组织相对于肝硬化组织,c-myb蛋白的表达明显增高（P=0.000）。结论提示,c-myb过表达是HCC发病中的早期事件,在HCC的发生、发展中可能起重要作用,检测c-myb的表达具有一定的临床意义。
- 肝细胞癌 /
- c-myb /
- 免疫组织化学
Abstract: Objective To study the expression of c-myb in human hepatocelluar carcinoma tissues, we explored its role in the occurrence and development of HCC and clinical significance.Methods The protein expressions of c-myb were detected in 55 HCC tissues, 55 peri-carcinoma tissues, 12 hepatic cirrhosis tissues and 11 normal liver tissues by immunohistochemistry.Results The expression of c-myb protein in HCC tissues compared with normal liver tissues, its expression in peri-carcinoma tissues compared with hepatic cirrhosis tissues were significantly higher (P=0.000) .Conclusion These suggested that overexpression of c-myb gene might be an early accidence in the pathogenesis of HCC, and might play an important role in the occurrence and development of HCC, detecting the expression of c-myb had clinical significance.
- hepatocellular carcinoma /
- c-myb /
- immunohistochemistry

HTML全文

参考文献(9)

[1]Darnell JE Jr. Transcription factors as targets for cancer therapy[J].Nat Rev Cancer, 2002, 2 (10) ∶740-749.

[2]Graf T.Myb:a transcriptional activatior linking proliferation and dif-ferentiation in hematopoietic cells[J].Curr Opin Genet Dev, 1992, 2 (2) ∶249-255.

[3]Thompson MA, Ramsay RG. Myb: an old oncoprotein with new roles[J].Bioessays, 1995, 17 (4) ∶341-350.

[4]Nyormoi O, Bar-Eli M. Transcriptional regulation of metastasis-related genes in human melanoma[J].Clin Exp Metastasis, 2003, 20 (3) ∶251-263.

[5]Ness SA.Myb binding proteins:regulators and cohorts in transforma-tion[J].Oncogene, 1999, 18 (19) ∶3039-3046.

[6]Weston K. Reassessing the role of C-MYB in tumorigenesis[J].Oncogene, 1999, 18 (19) ∶3034-3038.

[7]Gonda TJ. The c-Myb oncoprotein[J].Int J Biochem Cell Biol, 1998, 30 (5) ∶547-551.

[8]Zorbas M, Sicurella C, Bertoncello I, et al. c-Myb is critical for murine colon development[J].Oncogene, 1999, 18 (42) ∶5821-5830.

[9]Banyer JL, Hapel AJ.Myb-transformed hematopoietic cells as amodel for monocyte differentiation into dendritic cells and macropha-ges[J].J Leukoc Biol, 1999, 66 (2) ∶217-223.

施引文献

资源附件(0)

访问统计