IRIS13 C-美沙西汀呼气试验在肝硬化患者中的应用及评价

林言; 宋震亚; 范燕萍; 王海珍; 余永芳; 吴梦娟

IRIS13 C-美沙西汀呼气试验在肝硬化患者中的应用及评价

1. 宁波市第二医院消化内科

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中图分类号: R575.2
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出版历程
- 出版日期: 2008-02-20

The application and valuation of IRIS13 C-methacetin breath test in patients with cirrhosis.

摘要

摘要: 目的探讨13C-美沙西汀呼气试验在评估肝硬化患者肝功能状况中的临床应用价值。方法42例肝硬化患者,根据传统Child-Pugh分级分为A、B、C三组。均做常规肝功能生化检测及3C-美沙西汀呼气试验。结果随着Child-Pugh分级的加重,呼气试验参数值MVmax40（40分钟前代谢速率峰值与正常值（27）的比值）、CUM40（40分钟CO2累积呼出丰度与正常值（12）的比值）和CUM120（120分钟CO2累积呼出丰度与正常值（28）的比值）显著降低,组间差异有显著性（P<0.05）。三参数值与Child-Pugh分级计分及一些临床肝功能检测结果显著相关（P<0.05）。结论IRIS13C（红外线同位素13C）-美沙西汀呼气试验能准确反应肝脏储备和代偿功能,是传统Child-Pugh分级及临床肝功能生化检测评估肝功能的有益补充,具有即时、安全、有效、定量、无创的特点。
- 13C-美沙西汀呼气试验 /
- 肝硬化 /
- Child-Pugh肝功能分级 /
- 肝功能检测
Abstract: Objective To investigate the clinical value of 13C-methacetin breath test in the assessment of liver function in patients with cirrhosis.Methods 42 patients with liver cirrhosis were divided into three groups, 16 patients in Child-pugh classification A, 21in B and 5 in C.All received liver functional test and 13C-methacetin breath test at the same time.Results According to the severity of Child-pugh classification, the parameters of breath test: MVmax40 (a ratio between the maximum velocity before 40 minutes and the standard (27) , CUM40 (a ratio between the cumulative percentage 13C dose recovered over 40 minutes and the standard (12) and CUM120 (a ratio between the cumulative percentage 13C dose recovered over 120 minutes and the standard (28) ) were obviously reduced.The difference of them among these groups was significant (P<0.05) .The three parameters were significantly correlated with Child-pugh classification score and other clinical standard liver function tests (P<0.05) .Conclusion 13C-methacetin breath test can react to the liver functions of compensation and reservation actually.It is a helpful supplement technique of Child-pugh classification and clinical standards liver function tests, it is a test of instant, safe, effective, quantitative and non-invasive.
- 13C-methacetin breath test /
- liver cirrosis /
- liver function tests /
- Child-Pugh classification

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参考文献(8)

[1]Albers I, Hartmann H, Bircher J, et al.Superiority of the Child-Pugh-pugh classification to quantitative liver function tests for asses-sing prognosis of liver cirrhosis[J].Scand J Gastroenterl, 1989, 24∶269-276.

[2]中华医学会.病毒性肝炎防治方案[J].中华传染病杂志, 2001, 19 (1) ∶56-62.

[3]万荣、吴云林、丁进, 等.13C美沙西丁呼气试验对亚临床肝性脑病的临床价值分析[J].胃肠病学和肝病学杂志, 2004, 13 (3) ∶299-301.

[4]刘蕾、姚希贤、王天轶, 等.IRIS13C-美沙西汀呼气试验对肝功能检测临床价值及预后评估[J].胃肠病学和肝病学杂志, 2005, 14 (5) ∶493-496.

[5]Matsumoto K, Suehiro M, Iio M, et al.13C-methacetin breath testfor evaluation of liver damage[J].Dig Dis Sci, 1987, 32 (4) ∶344-348.

[6]Mikhn’ova NM, Shypulin VP.Role of13C-methacetin breath testin patients with chronic diffuse liver disease[J].Lik Sprava, 2001, (3) ∶155-158.

[7]丁进、万荣、叶静, 等.13C美沙西汀呼气试验联合血清胰岛素样生长因子及其结合蛋白测定对肝硬化患者肝功能状况的评估[J].胃肠病学和肝病学杂志, 2004, 13 (2) ∶175-178.

[8]Zipprich A, Meiss F, steudel N, et al.13C-Methacetin metabolismin patients with cirrhosis:relation to disease severity, haemoglobincontent and oxygen supply[J].Aliment Phamaeol Ther, 2003, 17 (12) ∶1559-1562.

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