Abstract: Objective To investigate the mechanisms and clinical significance on the alteration of QTc interval and QT dispersion in liver cirrhosis.Methods 116 liver cirrhosis patients and 50 control subjects were enrolled.Synchronic 12 leads electrocardiogram were used to calculate QTc and QTd in both groups, Prothrombin activity (PTA) 、Albumin (Alb) 、Total bilirubin (TBIL) 、Ascites and hepatic encephalopathy were detected in cirrhosis group.Results QTc prolongation incidence in cirrhotic patients was significant higher than controls (41.4% vs 4.0%, P<0.01) , QTd was also significant increased (48.7±18.6ms vs 34.6±11.1ms, P<0.05) .Multiple regression analysis showed QTc interval prolongation was positive correlated with Child-Pugh score、TBIL、ascite, while there was no correlation with PTA、Alb、HE.Conclusion In cirrhotic patients, QTc interval prolongation and QT dispersion increasing were co-contributed by multiple factors, and was one of the causes of sudden death due to provoke ventricular arrhythmia.