Study about ultrasonic and fibrosis parameters with diagnose of hepatic fibrosis
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摘要: 目的建立超声及血清纤维化指标组成的诊断方程,用无创性检查反映慢性乙型肝病肝纤维化某一阶段的病变程度。方法对慢性乙型肝炎及早期肝硬化患者,筛选出与肝纤维化有相关关系的超声和血清学指标共14项建立判别方程,利用ROC曲线确立诊断点。结果诊断轻度纤维化的方程1的曲线下面积为0.909,特异度为90.6%、灵敏度为82.9%;诊断S4的方程2的曲线下面积为0.943,特异度为89.0%、灵敏度为88.4%;将各病例的观察指标分别代入方程1、2其符合率分别为:88.1%、88.8%。结论彩超与血清肝纤维化四项指标建立的方程对肝纤维化分期有诊断价值,在一定程度上可逐步取代肝活组织检查。Abstract: Objective To develop a diagnostic model comprising ultrasonic and serum markers of fibrosis, reflect the severity of hepatic injury with non-invasive measure.Methods Patients with chronic hepatitis B or liver cirrhosis were selected;fourteen variables about ultrasonic and serum markers associated with liver fibrosis were performed and analyzed initially, then we developed a diagnostic model and confirmed the diagnostic point with ROC curve. Results In the model of mild fibrosis, the AUC was 0.909;the specificity was 90.6% and the sensitive was 82.9%.In the model about S4, the AUC was 0.943;the specificity was 89.0% and the sensitive was 88.4%.After taking the variables into the model one and two, the diagnosis efficacy respectively was 88.1% and 88.8%.Conclusion Ultrasonography and fibrosis parameters is valuable in determining the degree of hepatic fibrosis, it may be gradually applied in diagnosing liver fibrosis by replacing the invasive examination in a certain extent.
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Key words:
- hepatic fibrosis /
- US examination /
- ROC curve /
- diagnostic model
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