射频消融术对肝细胞肝癌患者特异性T淋巴细胞活性的影响

毕明俊; 李琴

射频消融术对肝细胞肝癌患者特异性T淋巴细胞活性的影响

毕明俊,
李琴

1. 荣成市第二人民医院外二科
2. 华中科技大学协和医院

详细信息

中图分类号: R735.7
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- 被引次数: 0
出版历程
- 出版日期: 2007-06-20

Bi MingJun,
Li Qin

摘要

摘要: 目的观察射频消融治疗对肝细胞肝癌患者特异性T淋巴细胞活性的影响。方法20例肝细胞肝癌患者随机分为两组:对照组(n=10)和射频组(n=10),所有患者均给予统一肝动脉插管化疗栓塞治疗(TACE),射频组加用射频消融术(RFA)。在治疗前、治疗后4w、8w分别采血样本。用APAAP法和LDH释放改良法分别检测外周血T细胞亚群及NK细胞活性。结果治疗前两组患者外周血T细胞亚群及NK细胞活性无显著差别(P>0.05);对照组治疗后4w外周血CD3、CD4、NK细胞活性略有升高,CD8略有下降,与治疗前相比无显著差别(P>0.05);射频组治疗后4w外周血CD3、CD4明显升高,CD8较前下降,CD4/CD8比值升高,与对照组相比,存在显著差异(P<0.05);与治疗前相比也存在差别(P<0.01),这种趋势一直持续到治疗后8w。结论RFA治疗后原发性肝癌患者显示明显T细胞刺激反应CD3、CD4,T细胞活性急剧增加。
- 射频消融 /
- 肝细胞肝癌 /
- T淋巴细胞活性 /
- 免疫反应

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参考文献(11)

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