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The correlation between TAP levels in plasma and urine and severity in patients with acute pancreatitis and their clinical significances
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摘要: 目的探讨血浆及尿液中胰蛋白酶原激活肽(TAP)与急性胰腺炎(AP)严重程度的相关性,为早期预测重症胰腺炎提供有临床价值的指标。方法采用ELISA法测定53例AP患者血浆及尿液中TAP水平,并将重症胰腺炎(SAP)与轻症胰腺炎(MAP)的TAP水平作对比。结果入院时AP患者血浆及尿中TAP水平均明显高于正常对照组(P均<0.01);重症AP组患者血浆及尿液中TAP水平均明显高于轻症AP组(P均<0.01)。结论血浆及尿液TAP水平变化与AP病情变化密切相关,病程早期检测血浆及尿液TAP水平有助于重症急性胰腺炎的预测。Abstract: Objective To investigate the correlation between TAP levels in plasma and urine and severity in patients with acute pancreatitis and their clinical significances.Methods the plasma and urinary TAP levels were measured with ELISA methods in 53 patients with acute pancreatitis (AP) and 30 normal subjects.Results the plasma and urinary TAP levels in AP patients were significantly higher than that in healthy people (P<0.01) .the plasma and urinary TAP levels in patients with severe acute pancreatitis were significantly higher than in those with mild acute pancreatitis (P<0.01) .Conclusion The plasma and urinary TAP levels are related to the development of acute pancreatitis, The measurement of plasma and urinary TAP may contribute to predict the severity of AP and guide clinical treatment.
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Key words:
- acute pancreatitis /
- trypsinogen activation peptides
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[1]Frossard JL.Trypsin activation peptide (TAP) in acute pancreatitis:frompathophysiology to clinical usefulness[J].JOP, 2001, 2 (2) ∶69-77. [2]Coelho AM, Machado MC, Cunha JE, et al.Influence of pancreaticenzyme content on experimental acute pancreatitis[J].Pancreas, 2003, 26 (3) ∶230-4. [3]Mansfield CS, Jones BR.Plasma and urinary trypsinogen activationpeptide in healthy dogs, dogs with pancreatitis and dogs with othersystemic diseases[J].Aust Vet J, 2000, 78 (6) ∶416-22. [4]Neoptolemos JP, Kemppainen EA, Mayer JM, et al.Early predictionofseverity in acute pancreatitis by urinary trypsinogen activation pep-tide:amulticentre study[J].Lancet, 2000, 355 (9219) ∶1955-1960. [5]Khan Z, Vlodov J, Horovitz J, et al.Urinary trypsinogen activationpeptide is more accurate than hematocrit in determining severity inpatients with acute pancreatitis:a prospective study[J].Am J Gas-troenterol, 2002, 97 (8) ∶1973-7. -
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