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The clinical significance of C-myc and P16 gene's expression in hepatocellular carcinoma
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摘要: 目的探讨C-myc基因和P16基因表达在肝细胞癌（HCC）中的临床意义。方法采用免疫组化检测技术检测不同肝癌组织、癌旁组织及正常肝组织中的C-myc基因和P16基因表达产物。结果C-myc基因表达产物在肝癌组织中的表达明显高于癌旁组织和正常肝组织（P<0.05）。P16基因表达产物则在正常肝组织中和癌旁组织中表达明显高于肝癌组织（P<0.05）。C-myc基因的表达与HCC的发病年龄、性别、肿瘤大小、UICC分期无关（P>0.05）,而与HCC的转移有关（P<0.05）;P16基因的表达与HCC的发病年龄、性别、肿瘤大小无关（P>0.05）,而与HCC的转移和UICC分期有关（P<0.05）。结论C-myc基因表达增强与P16基因表达障碍能促进HCC的发生发展,并可用来判断预后。Abstract: Objective To approach the clinical significance of C-myc and P16 gene's expression in hepatocellular carcinoma (HCC) .Methods C-myc and P16 gene's expression in HCC tissue and cancer adjacent liver tissue and normal liver tissue were detected by immunohistochemistry.Results The expression of C-myc in HCC tissue was higher than that in cancer adjacent liver tissue and normal liver tissue (P<0.05) .The expression of C-myc had no association with the patients'age, sex, the size of tumor and UICC stage (P>0.05) .It had some association with the patients'age, sex, the size of tumor (P>0.05) .The expression of P16 had some association with the UICC stage and the metastasis of HCC (P<0.05) .Conclusion The enhancement of expression of C-myc and the disorder of expression of P16 could promote the occurrence and development of HCC and could be used as prognostic factors.
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Key words:
- hepatocellular carcinoma /
- C-myc gene /
- P16 gene
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为使作者了解我刊的编辑出版计划，及时地为我刊惠赐稿件，《临床肝胆病杂志》编委会确定了2022年1-10期“重点号”选题及各期执行主编：
1期 大数据与人工智能赋能肝脏外科数字诊疗新时代····························································刘景丰
2期 儿童肝衰竭的诊断与治疗····························································王建设
3期 肝癌精准诊疗新进展····························································陈 磊
4期 自身免疫性肝病——识机制进展，促临床提升····························································闫惠平
5期 免疫治疗新时代下肝胆肿瘤治疗新进展····························································周 俭
6期 肝硬化门静脉高压的进展与挑战····························································陈金军
7期 非肝硬化性门静脉高压研究进展····························································徐小元
8期 从基础的视角看慢性乙型肝炎治愈及在研新药临床试验评价····························································鲁凤民
9期 肝硬化及其主要合并症的中西医结合治疗····························································刘 平
10期 期异种肝移植的发展与创新····························································窦科峰
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《临床肝胆病杂志》编辑部
2022年3月20日
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