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Study of the relationship of biological features of primary hepatocellular carcinoma and the characteristics of tumor microvessel
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摘要: 探讨肝细胞肝癌(HCC)生物行为学特性与肿瘤微血管特征的关系。收集手术切除的HCC标本52例,进行了肿瘤微血管密度(microvessel density,MVD)记数、微血管直径测量、梁索直径测量、肿瘤直径测量、细胞分化程度分级、癌栓、卫星结节观察。对肿瘤生物行为学特性和微血管特征观察指标进行统计分析。(1)HCC肿块大小与肿瘤MVD相关,与肿瘤微血管直径和肿瘤梁索直径呈正相关趋势;(2)有卫星结节、低分化HCC的MVD较高,肿瘤微血管直径较大;(3)有门脉癌栓的HCC的MVD较高。结论(1)HCC的MVD分布不均匀;(2)HCC在不同生长阶段、不同分化程度,其肿瘤微血管特征是不同的,并有一定的规律;(3)HCC临床生物学特性与肿瘤微血管特征之因果关系有待进一步探讨。Abstract: To discuss the relationship of the biological features of Primary hepatocellular carcinoma (HCC) and the characteristics of tumor microvessel.Collecting 52 carcinoma tissues resected surgically and observing the tumor size, differentiation degrees of the tumor, the cancer embolus of portal vein, the satellitic nubble of the tumor, the microvessels width of the tumor, trabecular diameter grade of the tumor and the tumor microvessel density (MVD) by Light microscopical study and immunohistochemistrial examination.The outcomes were statistically count. (1) With the increasing of the diameter of microvessel and width of tumor trabecular, the size of tumor has the tendency of increasing. (2) The MVD of the HCC having satellitic nubble and having lower differentiation degrees were higher, and the microvessels width of tumor were bigger. (3) The MVD of the HCC having cancer embolus of portal vein were higher.This shows: (1) The MVD of HCC were not even distributed in HCC. (2) The Characteristics of tumor microvessel in HCC in different vegetal phases and in different degrees were distinctive, and there were definite rule. (3) The causality between biological features of HCC and the characteristics of tumor microvessel will be further stdied.
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